Given their direct impact on the health and quality of life for millions, inhalers represent a major turning point in the history of modern medicine. Inhaler devices: Fundamentals, design and drug delivery provides readers with an introduction to the fundamentals of inhaler technology, with a comprehensive discussion of the history of inhalers as well as a discussion on current research and development. Part one discusses the fundamentals and development of inhaler devices as well as drug formulations for inhalers. The treatment of asthma is also discussed. Part two reviews recent developments in drug formulation and nanotechnology for inhaler devices, emerging inhaler technology and possible future trends. Inhaler devices: Fundamentals, design and drug delivery is an essential design guide for good industrial practice, and will be an invaluable resource for those researching and treating conditions such as asthma; and those developing and manufacturing inhalation devices.
Contributor contact details Woodhead Publishing Series in Biomaterials Preface Part I: Fundamentals and considerations of inhaler devices Chapter 1: Anatomy and pathophysiology of the respiratory system Abstract: 1.1 Introduction 1.2 Functional anatomy 1.3 Pathophysiology 1.4 Analysis of pathophysiology Chapter 2: History of inhaler devices Abstract: 2.1 Introduction 2.2 Structure and function of the lungs 2.3 Inhalers and successful therapy 2.4 Nebulisers 2.5 Pressurised metered-dose inhalers (pMDIs) 2.6 Dry powder inhalers 2.7 Future trends Chapter 3: Tribology of inhaler devices and components Abstract: 3.1 Introduction 3.2 Design and principles of pressurised metereddose inhalers (pMDIs) 3.3 Friction and lubrication within inhaler devices 3.4 Measuring friction between pMDI components Chapter 4: Novel coatings and biotechnology trends in inhaler devices Abstract: 4.1 Introduction 4.2 Current trends in inhaler devices 4.3 Novel coatings 4.4 Biotechnology Chapter 5: Microbial control and safety in inhalation devices Abstract: 5.1 Microbial cells 5.2 Growth of microorganisms in the environment 5.3 Microbial inactivation 5.4 Microbial contamination control 5.5 Keeping inhalers microbiologically safe Part II: Drug formulations for inhaler devices Chapter 6: Chitosan and inhalers: a bioadhesive polymer for pulmonary drug delivery Abstract: 6.1 Introduction 6.2 Chitosan-based inhaler drug delivery systems 6.3 The absorption enhancing effect of chitosan 6.4 Types of particle systems used in inhalers 6.5 Inhaler formulations based on chitosan and chitosan derivatives 6.6 Conclusions Chapter 7: Polyelectrolyte assemblies for drug storage and delivery: multilayers, nanocapsules and multicapsules Abstract: 7.1 Introduction 7.2 Layer-by-layer (LbL) multilayers for drug delivery applications: planar polyelectrolyte multilayers and capsules 7.3 Assembling of layer-by-layer multilayers 7.4 Variables affecting the electrostatic self-assembling 7.5 Properties of polyelectrolyte multilayers of interest in drug delivery 7.6 Encapsulation approximations 7.7 Encapsulating bioactive molecules 7.8 Strategies for releasing encapsulated drugs 7.9 Layer-by-layer capsules in drug delivery applications 7.10 Layer-by-layer capsules and inhalers 7.11 Conclusions 7.12 Acknowledgements Chapter 8: Functionalized core-shell nanoparticles for medical applications Abstract: 8.1 Introduction 8.2 New insights into copolymer-NSAID interactions 8.3 Materials and methods of interfacial and bulk studies of copolymer-drug aqueous systems 8.4 Experimental results and implications for intake and release mechanisms 8.5 Conclusions 8.6 Acknowledgements Index