This volume provides a comprehensive and state-of-the-art review on pediatric hematopoietic stem cell transplantation (HSCT). The book covers such topics as graft versus host disease (GVHD), HSC mobilization, stem cell selection, and HSCT-relevant laboratory assays and techniques. The text is specially formatted so that the scientific basis of HSCT and ethical considerations are integrated into the relevant clinical framework. Each chapter also includes diagrams, illustrations, and tables that summarize key points and concepts that can be used as a quick visual reference for the reader. Written by experts in the field, Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist is a valuable resource on pediatric HSCT suited for pediatric hematologists-oncologists, fellows, advanced practitioners, clinical nurses, and other referring physicians.
Part I. Introduction, History and the Basic Principles of Pediatric Hematopoietic Stem Cell Transplantation (HSCT)1. IntroductionValerie I. Brown2. Historical Overview of Pediatric HSCT Valerie I. Brown3. Brief Introduction to the Basic Principles of HSCT Valerie I. BrownPart II. Topics Related to the Pre- HSCT Period4. Pre-Transplantation: Indications and Timing Alicia McFarren and Michael A. Pulsipher5. Spotlight on Minimal residual Disease (MRD): Impact of MRD on HSCT Outcomes Hirsham Abdel-Azim and Michael A. Pulsipher6. HSCT Recipient Pre-Transplantation Evaluation Carrie Eichelberger and Valerie I. Brown7. How to Select a Donor and Hematopoietic Stem Cell Source: Related versus Unrelated Donors for Allogeneic HSCT Malika Kapadia and Robert Greiner 8. Donor Evaluation, Selection and Hematopoietic Stem Cell Mobilization, Procurement and Manipulation William Ferguson and Aleksander Babic9. Preparing the Patient for HSCT: Conditioning Regimens and their Scientific Rationale Carrie Kitko, Katie Gatwood, James ConnellyPart III. The Peri- HSCT Period: Pre-Engraftment (Days 0-30) and Early Post- HSCT (Days 30-100) Periods10. Engraftment and Chimerism Valerie I. Brown11. Graft Failure Valerie I. Brown12. Engraftment Syndrome and Associated Cytokine Storm and Capillary Leak Syndrome Mala K. Talekar and Jason L. Freedman13. Nutrition in the Peri-HSCT Period Arun Gurunathan, Judy Bailer, Jason L. Freedman14. Mucositis and Pain in the Peri- HSCT Period Arun Gurunathan, Neil S. Patel, Jason L. Freedman15. Hepatoxicity in the Peri- HSCT Period Valerie I. Brown16. Renal Toxicity in the Peri- HSCT Period Malika Kapadia, Terry Shapiro and Robert Greiner17. Infectious Complications and HSCT Karen Bride, Ellen Levy, Anne Wohlschlaeger, Jason L. Freedman18. Acute Graft Versus Host Disease: Diagnosis, Prophylaxis and Treatment Karen L. Bride, Neil S. Patel, Jason L. FreedmanPart IV. The Late Post- HSCT Period (> 100 Days)19. Chronic GVHD Terry Wikle Shapiro, Malika Kapadia<20. Hematologic Complications Associated with HSCT Mala K. Talekar and Timothy Olson21. Pulmonary Complications Associated with HSCT Malika Kapadia and Terry Shapiro22. Renal Complications Associated with HSCT Lena E. Winestone, Alix E. Seif, Benjamin L. Laskin23. Cardiac Complications Associated with HSCT Valerie I. Brown24. Neurologic and Sensory Complications Associated with HSCT Valerie I. Brown25. HSCT-Associated Complications of the Skin, Hair and Nails Valerie I. BrownPart V: Life After HSCT26. Immune Reconstitution after Hematopoietic Stem Cell Transplantation Mala K. Talekar and Timothy Olsen27. Life After HSCT: Survivorship and Long-Term Issues Smita DandekarPart VI. Pharmacologic-Related Issues of Pediatric HSCT28. Medications commonly Used in Pediatric HSCT Kevin Mulieri, Ashley Teusink-Cross, JoEllen Wellnau, Krisoula Horiates, Katie S. Gatwood