Main description:

This book gives a very timely account of recent - partly unpublished - research on the development of gram-positive bacteria as vaccine delivery vehicles for mucosal immunization. The practical and theoretical considerations are discussed and the basic concepts behind the different approaches are compared by giving specific examples of the use of different non-pathogenic bacteria as vaccine vehicles. Thus, a common framework of concepts for a new generation of mucosal vaccines is provided.

Contents:

1. An Overview of Gram-Positive Bacteria as Vaccine Vehicles for Mucosal Immunization.- 2. Dendritic Cells as Targets for Mucosal Immunization.- 3. Recombinant Streptococcus gordonii as a Live Vehicle for Vaccine Antigens.- 4. Development of Non-Pathogenic Staphylococci as Vaccine Delivery Vehicles.- 5. Mucosal Immunization with Recombinant Lactococcus lactis.- 6. Expression of Vaccine Antigens in Lactobacillus.- 7. Listeria monocytogenes - a Promising Vaccine Carrier to Evoke Cellular Immune Responses.