(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled "Artificial Self-Assembling Systems for Gene Transfer", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: * size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . * potential tumorigenesis (e. g. retrovirus) * potential for insertional mutagenesis (greater than plasmid based systems) * potential imrnunogenicity (e. g.
Contents:
Preface: Molecular and Mechanical Aspects of Gene Transfer; K.L. March. Acknowledgements. Vectors and Gene Transfer Systems: Molecular Aspects of Delivery. 1. Development of Viral Vectors for Human Gene Therapy; Retrovirus and Adenovirus (Part I); B.C. Trapnell, M.N. Pensiero. 2. Adenoviruses (Part II): Improvement of Adenoviral Vectors for Human Gene Therapy: E1 and E4 Deleted Recombinant Adenoviruses; J.F. Dedieu, et al. 3. Adeno-Associated Virus and Other New DNA Virus Vectors; T.R. Floote, et al. 4. Plasmid and Other Non-Viral Vectors; L.B. Jacobsen. 5. The HVJ/Liposome Molecular Delivery System for In Vivo Genetic Engineering; G.H. Gibbons. 6. Endogenous Expression Modification: Antisense Approaches; M. Simons. Methods for Localizing Gene Transfer: Mechanical Aspects of Delivery. 7. Catheter-Based Local Drug and Gene Delivery; R.L. Wilensky. 8. Fluid Dynamics of Catheter Delivery: Effects on Delivery Efficiency and Localization; C.R. Lambert, S. Rowland. 9. Targeted and Sustained-Release Delivery Concepts in Gene Therapy; R.W. Schroff, L.L. Kunz. Gene Delivery For Local Vascular Expression. 10. Viral Vector-Based Vascular Gene Delivery: Basic Studies and Therapeutic Applications; E.G. Nabel. 11. Cell-Based Vascular Gene Delivery: Endothelial Cells as Carriers; J. Burke, et al. 12. Cell-Based Gene Delivery: Smooth Muscle Cells as Carriers; A.W. Clowes. 13. Vascular Cell Proliferation Dynamics: Implications for Gene Transfer and Restenosis; R.S. Schwartz, et al.14. Angiogenesis and Collateral Formation; J.M. Isner. Gene Delivery for Local Cardiac Expression. 15. Cell-Based Myocardial Protein Delivery; M.H. Soonpaa, L.J. Field. 16. Skeletal Myoblast Therapy in Cardiovascular Disease; D.A. Taylor, et al. 17. Adenovirus and the Myocardium; J.A. Towbin. Gene Delivery for Systemic Expression. 18. Gene Delivery for Systemic Expression: Plasmid, Retroviral, and Adenoviral Approaches; K. Parker Ponder. 19. Adenoviral Gene Delivery Approaches for Systemic Expression; S.C. Stevenson, A. McClelland. 20. Experimental Approaches Using Kallikrein Gene Therapy for Hypertension; J. Chao, L. Chao. Biophysical Considerations in Vector Delivery. 21. Pharmacokinetics of Local Vector Delivery to Vascular Tissues: Implications for Efficiency and Localization; K.L. March, B. Trapnell. Color Plates. Index.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: October, 2012
Pages: 538
Weight: 819g
Availability: Available
Subcategories: Cardiovascular Medicine, Genetics
From the same series
Jean-Claude Tardif
Xander H T Wehrens
Johan H. C. Reiber
Raimund Erbel
M.P. Sambhi
Pedro Brugada
W. Bleifeld
Naranjan S. Dhalla
Bohuslav Ostadal
Ralph Shabetai
Jason X.-J. Yuan
Hein J.J. Wellens
R. C. Becker
Franz H. Messerli
C.H. Peels
Stephen M. Factor
Hiroyuki Suga
Hugo Ector
Brian E. Jaski
Richard A. Walsh
Seymour Glagov
Michiel J. Janse
Lloyd W. Klein
Thomas H Marwick
Ernst E. van der Wall
P.J. Walter
Ernst E. van der Wall
Ernst E. van der Wall
A-M. Salmasi
Michel Emile Safar
A-M. Salmasi
Ernst E. van der Wall
Andrea Natale
Albert de Roos
C.A. Nienaber
Guillem Pons-Llado
Vinzenz Hombach
R. Vos
J. Candell-Riera
R.W. Stout
Peter Hanrath
Johan H. C. Reiber
P.A.F.M. Doevendans
Jack Rychik
P.A.F.M. Doevendans
P.E. Vardas
Makoto Nagano
George D. Dangas
Myrvin H. Ellestad
C.J. Preusse
Thomas H Marwick
Thomas H Marwick
Ernst E. van der Wall
G.T. Meester
A.G. Herman
J.C. Tardif
P.J. Walter
Johan H. C. Reiber
Ernst E. van der Wall
Lloyd W. Klein
Akira Matsumori
Robert L. Wilensky
Bernard Swynghedauw
Juan Carlos Kaski
Franz H. Messerli
John F. Keaney Jr.
Naranjan S. Dhalla
Zainul Abedin
Juan Carlos Kaski
Eric J Topol
A.V. Bruschke
Richard C. Becker
J. Candell-Riera
Ghassan Bkaily
Lionel H. Opie
Bernard Swynghedauw
Geoffrey Burnstock
P. Cummins
Nicholas Sperelakis
Mina Rajskina
A.A. Knowlton
Johan H. C. Reiber
Irene D. Turpie
J. A. E. Spaan
Ernst E. van der Wall
Masatsugu Hori
Bing Liem Liong
R. Fagard
M. Iwase
R. Stroobandt
A.V. Bruschke
David M. Mirvis
Franz H. Messerli
G. Assmann
Melvin Scheinman
J. Morganroth
J.W. de Jong
M.B. Rosenbaum
C. Tissa Kappagoda
H.V. Villareal
J. Morganroth
Ernst E. van der Wall
Naranjan S. Dhalla
H. Mitchell Perry Jr.
M.P. Spencer
Henk Keurs
C.T. Lancée
J.R. Roelandt
G.S. Wagner
H. Kesteloot
A.C. Arntzenius
Johan H. C. Reiber
A. Maseri
Michel Emile Safar
M.P. Spencer
W. Bleifeld
Henk Keurs
Willem H. Birkenhager
Antonio Bayes de Luna
J.R. Roelandt
Naranjan S. Dhalla
H. Rijsterborgh
Marianne J. Legato
Naranjan S. Dhalla
S. Chien
Rafael Beyar
H.E. Van Dam
M.P. Spencer
J.R. Roelandt
Hilbert J.Th. Thalen
C. Marchesi
J.P.M Hamer
Rafael Beyar
L.N. Bouman
A. Alboni
Douglas P. Zipes
Nicholas Sperelakis
Borys Surawicz
Antonio Bayes de Luna
Johan H. C. Reiber
Hein J.J. Wellens
J.V. Chapman
E. Aliot
Vinzenz Hombach
Michael R. Rosen
William H. Gaasch
Pawan K. Singal
Robert Plonsey
H.L. Stone
J. Soler-Soler
Ernst E. van der Wall
Michel Emile Safar
J. Morganroth
Hein J.J. Wellens
J.R. Roelandt
Vinzenz Hombach
Richard S. Meltzer
Marvin A. Konstam
Naranjan S. Dhalla
Naranjan S. Dhalla
S.N. Willich
Johan H. C. Reiber
C.A. Nienaber
Ernst E. van der Wall
Robert J. Siegel
Markus Schwaiger
Andrew Wechsler
Elliot Rapaport
Naranjan S. Dhalla
John E. Tooke
Derek Yellon
Henk Keurs
Steve M. Teague
J.W. de Jong
Naranjan S. Dhalla
Nicholas Sperelakis
P.H. Heintzen
J. Morganroth
John B. Lombardini
Adam Schneeweiss
J.R. Roelandt
Naranjan S. Dhalla
Naranjan S. Dhalla
J.C. Chatham
Pim J. de Feyter
David W. Holt
Catherine A. Neill
J. Roelandt
A.P. Shepherd
Gastone Leonetti
Nico H.J. Pijls
K. Robinson
P.A.F.M. Doevendans
Douglas P. Zipes
Jose Marin-Garcia
Jonathan S. Steinberg
Francisco Villarreal
Dick Macdonald
Ragavendra R. Baliga
Dick Macdonald