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Main description:
Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders.
Contents:
Part i: Vectors and Promoters. Introduction, J. Glorioso. Retrovirus Vectors and Regulatable Promoters, S. Reeves. Adenovirus Vectors, M. Cotten. Herpes Simplex Virus: Recombinant Vectors, P. A. Johnson. Herpes Simplex Virus: Amplicon Vectors, C. Fraefel, X. O. Breakefield, and D. Jacoby. Adeno-Associated Virus Vectors, F. I. Smith and T. J. McCown. Epstein-Barr Virus Vectors, J.-M. H. Vos, K. B. Quattrocchi, and B. J. Wendelburg. Lentiviral Vectors, D. Trono, U. Blomer, and L. Naldini. Promoters for Expression of Gene Products Within Neurons and Glia, J. W. Henson. Immunological Issues, J. G. Smith and S. L. Eck. Part ii: Neuro-oncology. Current Treatment Modalities for Brain Tumor, S. B. Tatter and G. R. Harsh IV. Experimental and Clinical Gene Therapies for Brain Tumors, E. A. Chiocca. Tumor Suppressor Gene Therapy for Brain Tumors, C. Gomez-Manzano, J. Fueyo, A. P. Kyritsis, W.K. A. Yung. Cytokine-Based Gene Therapy for Brain Tumors, J. H. Sampson, D. D. Bigner, and G. Dranoff. Delivery of Therapeutic Genes to Brain and Intracerebral Tumors, L. L. Muldoon, R. A. Kroll, M. A. Pagel, S. Roman-Goldstein, and E. A. Neuwelt. Rat Brain Tumor Models and Statistical Evaluation of Survival Data in Experimental Neuro-Oncology, R. F. Barth and M. L. Moeschberger. Part iii: Neurological Disorders. Neurological Disorders: An Overview, A. B. Young. Gene Transfer for Adult CNS Regeneration and Aging, M.C. Senut, I. Aubert, P.J. Horner, and F. H. Gage. Gene Therapy for Parkinson's Disease, M. C. Bohn and D. L. Choi-Lundberg. Gene Therapy for Ischemic Stroke, P. A. Pechan, M. Fujii, C. Fraefel, Andreas Jacobs, and M. A. Moskowitz. Gene Therapy for the Lysomal Storage Diseases, E. M. Kaye. Gene Therapy for Pain, G. Davar. Gene Therapy of Huntington's Disease, O. Isaesen and N. Haque. Index.
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: March, 2013
Pages: 458
Weight: 898g
Availability: Available
Subcategories: Neuroscience
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