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Epigenetics in Health and Disease
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Main description:

This is the first comprehensive, authoritative, and easy-to-understand introduction to modern epigenetics. Authored by two active researchers in the field, it introduces key concepts one step at a time, enabling students at all levels to benefit from it. The authors begin by presenting a historical overview that places epigenetics in context, and makes it clear that the field is not (as some presume) completely new. Next, they introduce and explain key epigenetic mechanisms, and discuss the roles these mechanisms may play in inheritance, organism development, health and disease, behavior, evolution, ecology, and the interaction of individual organisms with their environments. Coverage includes: non-coding RNAs in each kingdom; allelic interactions; CRYSPR; gene silencing; epigenetics of germline and epigenetic memory; epigenetic regulation of genome stability and plant stress response; and much more. The authors conclude by offering significant new insights into how knowledge of epigenetics and epigenomics may promote the development of technologies and solutions in areas ranging from behavioral neuroscience to cancer treatment, toxicology to the development of hardier crops.


Contents:

Chapter 1 Historical Perspective 1 Chapter 2 Chromatin Dynamics and Chromatin Remodeling in Animals 19 Chapter 3 Chromatin Dynamics and Chromatin Remodeling in Plants 49 Chapter 4 DNA Methylation as Epigenetic Mechanism 75 Chapter 5 Histone Modifications and Their Role in Epigenetic Regulation 119 Chapter 6 Realm of Non-Coding RNAs--From Bacteria to Human 147 Chapter 7 Non-Coding RNAs Involved in Epigenetic Processes--A General Overview 177 Chapter 8 Non-Coding RNAs Across the Kingdoms--Bacteria and Archaea 203 Chapter 9 Non-Coding RNAs Across the Kingdoms--Protista and Fungi 223 Chapter 10 Non-Coding RNAs Across the Kingdoms--Animals 267 Chapter 11 Non-Coding RNAs Across the Kingdoms--Plants 297 Chapter 12 Non-Coding RNAs--Comparison of Biogenesis in Plants and Animals 327 Chapter 13 Paramutation, Transactivation, Transvection, and Cosuppression--Silencing of Homologous Sequences 343 Chapter 14 Bacterial Adaptive Immunity--Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) 385 Chapter 15 Gene Silencing--Ancient Immune Response and a Versatile Mechanism of Control over the Fate of Foreign Nucleic Acids 409 Chapter 16 Epigenetics of Germline and Epigenetic Memory 435 Chapter 17 Epigenetics of Health and Disease--Cancer 465 Chapter 18 Epigenetics of Health and Disease--Behavioral Neuroscience 499 Chapter 19 Epigenetics of Health and Disease--Diet and Toxicology, Environmental Exposures 523 Chapter 20 Epigenetics and Technology--Hairpin-Based Antisensing 555 Index 577


PRODUCT DETAILS

ISBN-13: 9780132597081
Publisher: Financial TImes Prentice Hall
Publication date: May, 2012
Pages: 608
Dimensions: 190.00 x 233.00 x 38.00
Weight: 922g
Availability: Contact supplier
Subcategories: Genetics

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