Main description:

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the wide range of often difficult-to-diagnose variants and subtypes in soft tissue tumors, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the fourth edition of Diagnostic Pathology: Soft Tissue Tumors is a visually stunning, one-stop resource for every practicing pathologist, oncologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.

Provides up-to-date, comprehensive coverage of soft tissue pathology combined with accurate, concise clinicopathologic descriptions, helping you quickly identify tumors and establish actionable diagnoses

Contains hundreds of chapters with separate Benign, Intermediate, and Malignant sections to provide the fullest diagnostic picture possible

Features new chapters covering the recently recognized EWSR1::SMAD3 fibroblastic tumor, plexiform myofibroblastoma, anastomosing hemangioma, myxoid pleomorphic liposarcoma, and more

Includes details throughout on new immunostains and molecular genetics and testing

Features an image-rich layout with more than 4,200 print and online-only images-including high-quality photomicrographs, gross photographs, radiologic images, and detailed medical illustrations-to make tumor identification and diagnosis faster and easier

Provides an organized framework that includes "Approach to Diagnosis" chapters designed to help you successfully recognize and diagnose challenging soft tissue tumors with the availability of common patterns and histologic features

Includes updates based on the most recent WHO Classification of Tumors: Soft Tissue and Bone Tumors

Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care

Includes an eBook version that enables you to access all text, figures, and references with the ability to search, customize your content, make notes and highlights, and have content read aloud

Contents:

SECTION 1: SOFT TISSUE INTRODUCTION

INTRODUCTION AND OVERVIEW

4 Gross Examination

Matthew R. Lindberg, MD

6 Grading and Staging

Matthew R. Lindberg, MD

ANCILLARY TECHNIQUES

12 Soft Tissue Immunohistochemistry

Matthew R. Lindberg, MD

18 Molecular Features of Soft Tissue Tumors

Matthew R. Lindberg, MD

SECTION 2: DIAGNOSTIC APPROACH TO SOFT TISSUE TUMORS

OVERVIEW

22 Biopsy and Resection of Soft Tissue Tumors

Matthew R. Lindberg, MD

CLINICAL APPROACH

26 Age- and Location-Based Approach to Diagnosis

Matthew R. Lindberg, MD

HISTOLOGIC APPROACH

28 Pattern-Based Approach to Diagnosis

Matthew R. Lindberg, MD

36 Feature-Based Approach to Diagnosis

Matthew R. Lindberg, MD

SECTION 3: TUMORS OF ADIPOSE TISSUE

BENIGN

46 Lipoma

Matthew R. Lindberg, MD

52 Lipomatosis of Nerve

Michella Whisman, MD and Jerad M. Gardner, MD

54 Synovial Lipomatosis

Matthew R. Lindberg, MD

56 Angiolipoma

Michella Whisman, MD and Jerad M. Gardner, MD

60 Spindle Cell/Pleomorphic Lipoma

Matthew R. Lindberg, MD

66 Chondroid Lipoma

Matthew R. Lindberg, MD

70 Myolipoma

Michella Whisman, MD and Jerad M. Gardner, MD

74 Hibernoma

Matthew R. Lindberg, MD

78 Myelolipoma

Matthew R. Lindberg, MD

80 Lipoblastoma

Matthew R. Lindberg, MD

84 Atypical Spindle Cell/Pleomorphic Lipomatous Tumor

Matthew R. Lindberg, MD

88 Lipoblastoma-Like Tumor of Vulva

Matthew R. Lindberg, MD

INTERMEDIATE, LOCALLY AGGRESSIVE

92 Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma

Matthew R. Lindberg, MD

MALIGNANT

98 Dedifferentiated Liposarcoma

Matthew R. Lindberg, MD

106 Myxoid Liposarcoma

Matthew R. Lindberg, MD

112 Pleomorphic Liposarcoma

Matthew R. Lindberg, MD

118 Myxoid Pleomorphic Liposarcoma

Matthew R. Lindberg, MD

SECTION 4: FIBROBLASTIC/MYOFIBROBLASTIC LESIONS

BENIGN

124 Nodular Fasciitis

Matthew R. Lindberg, MD

130 Proliferative Fasciitis/Myositis

Matthew R. Lindberg, MD

134 Ischemic Fasciitis

Matthew R. Lindberg, MD

136 Myositis Ossificans

Matthew R. Lindberg, MD

140 Fibroosseous Pseudotumor of Digits

David Lucas, MD and Elizabeth A. Montgomery, MD

144 Fibroma of Tendon Sheath

David Lucas, MD

150 Desmoplastic Fibroblastoma

David Cassarino, MD, PhD and Khin Thway, MD, FRCPath

152 Elastofibroma

Matthew R. Lindberg, MD

154 Angiofibroma of Soft Tissue

Matthew R. Lindberg, MD 158 Mammary-Type Myofibroblastoma

Matthew R. Lindberg, MD

162 Plexiform Myofibroblastoma

Matthew R. Lindberg, MD

166 Intranodal Palisaded Myofibroblastoma

Matthew R. Lindberg, MD

170 Pleomorphic Fibroma

David Cassarino, MD, PhD

172 Dermatomyofibroma

David Cassarino, MD, PhD

174 Fibroblastic Connective Tissue Nevus

Matthew R. Lindberg, MD

176 Storiform Collagenoma

David Cassarino, MD, PhD

178 Keloid

David Cassarino, MD, PhD

180 Nuchal-Type Fibroma

Matthew R. Lindberg, MD

INTERMEDIATE (LOCALLY AGGRESSIVE)

182 Palmar/Plantar Fibromatosis

Matthew R. Lindberg, MD

184 Desmoid-Type Fibromatosis

Matthew R. Lindberg, MD

190 EWSR1::SMAD3 Fibroblastic Tumor

Matthew R. Lindberg, MD

INTERMEDIATE (RARELY METASTASIZING)

194 Dermatofibrosarcoma Protuberans

Matthew R. Lindberg, MD

204 Solitary Fibrous Tumor

Matthew R. Lindberg, MD

212 Low-Grade Myofibroblastic Sarcoma

Matthew R. Lindberg, MD

216 Inflammatory Myofibroblastic Tumor

Matthew R. Lindberg, MD

222 Myxoinflammatory Fibroblastic Sarcoma

Matthew R. Lindberg, MD

230 Superficial CD34(+) Fibroblastic Tumor

Matthew R. Lindberg, MD

MALIGNANT

234 Adult-Type Fibrosarcoma

Michella Whisman, MD and Jerad M. Gardner, MD

236 Myxofibrosarcoma

Matthew R. Lindberg, MD

242 Low-Grade Fibromyxoid Sarcoma

Matthew R. Lindberg, MD

252 Sclerosing Epithelioid Fibrosarcoma

Matthew R. Lindberg, MD

258 Epithelioid Inflammatory Myofibroblastic Sarcoma

Matthew R. Lindberg, MD

SECTION 5: PEDIATRIC FIBROBLASTIC/MYOFIBROBLASTIC TUMORS

BENIGN

264 Fibrous Hamartoma of Infancy

Matthew R. Lindberg, MD

268 Calcifying Aponeurotic Fibroma

Matthew R. Lindberg, MD

272 Calcifying Fibrous Tumor

Michella Whisman, MD, Kandi Stallings-Archer, MD, and Elizabeth A. Montgomery, MD

274 Inclusion Body Fibromatosis

Matthew R. Lindberg, MD

276 Hyaline Fibromatosis Syndrome

Michella Whisman, MD, Elizabeth A. Montgomery, MD, and Cyril Fisher, MD, DSc, FRCPath

278 Fibromatosis Colli

Michella Whisman, MD, Kandi Stallings-Archer, MD, and Cyril Fisher, MD, DSc, FRCPath

280 Gardner Fibroma

Michella Whisman, MD and Jerad M. Gardner, MD

INTERMEDIATE (LOCALLY AGGRESSIVE)

282 Lipofibromatosis

Michella Whisman, MD, Kandi Stallings-Archer, MD, and Elizabeth A. Montgomery, MD

284 Giant Cell Fibroblastoma

Matthew R. Lindberg, MD

INTERMEDIATE (RARELY METASTASIZING)

288 Infantile Fibrosarcoma

Matthew R. Lindberg, MD

SECTION 6: FIBROHISTIOCYTIC, HISTIOCYTIC, AND DENDRITIC CELL TUMORS

BENIGN

294 Dermatofibroma and Fibrous Histiocytoma

David Cassarino, MD, PhD

300 Deep Benign Fibrous Histiocytoma

Matthew R. Lindberg, MD

302 Epithelioid Fibrous Histiocytoma

David Cassarino, MD, PhD

306 Localized-Type Tenosynovial Giant Cell Tumor

David Lucas, MD

312 Diffuse-Type Tenosynovial Giant Cell Tumor

David Lucas, MD

318 Cellular Neurothekeoma

Michella Whisman, MD, Jerad M. Gardner, MD, and Cyril Fisher, MD, DSc, FRCPath

322 Xanthomas

Matthew R. Lindberg, MD

326 Solitary (Juvenile) Xanthogranuloma

David Cassarino, MD, PhD and Elizabeth A. Montgomery, MD 328 Reticulohistiocytoma

David Cassarino, MD, PhD

332 Deep Granuloma Annulare

Nicholas Zoumberos, MD and Jerad M. Gardner, MD

334 Rheumatoid Nodule

Nicholas Zoumberos, MD and Jerad M. Gardner, MD

336 Langerhans Cell Histiocytosis

Matthew R. Lindberg, MD

338 Extranodal Rosai-Dorfman Disease

Matthew R. Lindberg, MD

342 Crystal-Storing Histiocytosis

Matthew R. Lindberg, MD and Elizabeth A. Montgomery, MD

INTERMEDIATE (RARELY METASTASIZING)

344 Plexiform Fibrohistiocytic Tumor

Matthew R. Lindberg, MD

348 Giant Cell Tumor of Soft Tissue

David Lucas, MD

MALIGNANT

352 Histiocytic Sarcoma

Matthew R. Lindberg, MD

354 Follicular Dendritic Cell Sarcoma

Matthew R. Lindberg, MD

358 Interdigitating Dendritic Cell Sarcoma

Matthew R. Lindberg, MD, L. Jeffrey Medeiros, MD, and Cyril Fisher, MD, DSc, FRCPath

SECTION 7: SMOOTH MUSCLE TUMORS

BENIGN

362 Smooth Muscle Hamartoma

Nicholas Zoumberos, MD and Jerad M. Gardner, MD

364 Superficial Leiomyoma

Nicholas Zoumberos, MD, Jerad M. Gardner, MD, and Jonathan B. McHugh, MD

368 Deep Leiomyoma

Matthew R. Lindberg, MD

INTERMEDIATE

372 Epstein-Barr Virus-Associated Smooth Muscle Tumor

David Lucas, MD

MALIGNANT

374 Leiomyosarcoma

Matthew R. Lindberg, MD

SECTION 8: PERICYTIC (PERIVASCULAR) TUMORS

BENIGN

382 Glomus Tumors (and Variants)

Thomas Mentzel, MD and Matthew R. Lindberg, MD

388 Myopericytoma

Matthew R. Lindberg, MD and Thomas Mentzel, MD

392 Myofibroma and Myofibromatosis

Matthew R. Lindberg, MD

396 Angioleiomyoma

Matthew R. Lindberg, MD

SECTION 9: TUMORS OF SKELETAL MUSCLE

BENIGN

400 Focal Myositis

Matthew R. Lindberg, MD and Cyril Fisher, MD, DSc, FRCPath

402 Adult Rhabdomyoma

Matthew R. Lindberg, MD

404 Fetal Rhabdomyoma

Matthew R. Lindberg, MD

406 Genital Rhabdomyoma

Matthew R. Lindberg, MD

408 Cardiac Rhabdomyoma

Matthew R. Lindberg, MD

MALIGNANT

410 Embryonal Rhabdomyosarcoma

Matthew R. Lindberg, MD

416 Alveolar Rhabdomyosarcoma

Matthew R. Lindberg, MD

422 Spindle Cell/Sclerosing Rhabdomyosarcoma

Matthew R. Lindberg, MD

426 Pleomorphic Rhabdomyosarcoma

Michella Whisman, MD and Jerad M. Gardner, MD

430 Epithelioid Rhabdomyosarcoma

Matthew R. Lindberg, MD

SECTION 10: VASCULAR TUMORS (INCLUDING LYMPHATICS)

BENIGN

434 Papillary Endothelial Hyperplasia

David Cassarino, MD, PhD and Amitabh Srivastava, MD

436 Bacillary Angiomatosis

David Cassarino, MD, PhD

438 Cutaneous Epithelioid Angiomatous Nodule

Matthew R. Lindberg, MD

440 Congenital Hemangioma

Michella Whisman, MD and Kandi Stallings-Archer, MD

444 Infantile Hemangioma

Michella Whisman, MD and Kandi Stallings-Archer, MD

448 Lobular Capillary Hemangioma

Matthew R. Lindberg, MD

450 Epithelioid Hemangioma

Matthew R. Lindberg, MD

454 Spindle Cell Hemangioma

Michella Whisman, MD and Jerad M. Gardner, MD

458 Intramuscular Angioma

Matthew R. Lindberg, MD and Jonathan B. McHugh, MD

462 Hobnail Hemangioma

David Cassarino, MD, PhD

464 Acquired Tufted Angioma

David Cassarino, MD, PhD

466 Microvenular Hemangioma

David Cassarino, MD, PhD

468 Sinusoidal Hemangioma

David Cassarino, MD, PhD

470 Glomeruloid Hemangioma

David Cassarino, MD, PhD

472 Anastomosing Hemangioma

Matthew R. Lindberg, MD

476 Synovial Hemangioma

Matthew R. Lindberg, MD

478 Angiomatosis

David Lucas, MD

480 Lymphangioma

David Cassarino, MD, PhD

484 Massive Localized Lymphedema

Matthew R. Lindberg, MD

486 Atypical Vascular Lesion

David Lucas, MD

INTERMEDIATE (LOCALLY AGGRESSIVE)

488 Kaposiform Hemangioendothelioma

David Lucas, MD

INTERMEDIATE (RARELY METASTASIZING)

490 Papillary Intralymphatic Angioendothelioma

David Cassarino, MD, PhD

492 Retiform Hemangioendothelioma

David Cassarino, MD, PhD