Main description:

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of common and rare nonneoplastic renal diseases, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, Diagnostic Pathology: Kidney Diseases, fourth edition, is a visually stunning, one-stop resource for every practicing pathologist, nephrologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.

Provides a comprehensive source for key pathologies and clinical features of more than 265 kidney diseases

Features two dozen new chapters on a variety of timely topics, including COVID-19 nephropathies, xenografts, artificial intelligence (AI), digital pathology analysis, harmonized nephropathology terminology, newly identified types of amyloidosis, common artifacts and pitfalls on kidney biopsy, vaccination-associated renal disease, crystal nephropathies, and much more

Includes updates from the International Kidney and Monoclonal Gammopathy (IKMG) research group, the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for IgG4-related disease, Banff Foundation for Allograft Pathology, and others

Details updated genetic causes of nephrotic syndromes and antinephrin antibodies in podocytopathies-by the investigator who discovered it

Discusses the newly identified variant IgG nephropathy and novel membranous autoantigens

Contains chapters on techniques, including immunofluorescence on paraffin sections, C4d staining, and polyomavirus detection in tissue

Contains more than 4,300 print and online images, including high-resolution photographs and histologic images, full-color medical illustrations, radiologic images, and more

Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care

Shares the expertise of internationally recognized authors who provide fresh perspectives on multiple topics, with a particular emphasis on practical information that directly assists in making and supporting a diagnosis

Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud

Contents:

SECTION 1: INTRODUCTION AND OVERVIEW

4 Introduction to Renal Pathology

Robert B. Colvin, MD

24 Normal Kidney Structure

Neeraja Kambham, MD and Anthony Chang, MD

36 Normal Kidney Development

Sanjay Jain, MD, PhD and Yasar Caliskan, MD

46 Kidney Biopsy Evaluation and Reports

Lynn D. Cornell, MD, Surya V. Seshan, MD, and Anthony

Chang, MD

50 Harmonized Nephropathy Terminology

Mark Haas, MD

54 Common Artifacts and Pitfalls

Lynn D. Cornell, MD

SECTION 2: GLOMERULAR DISEASES

PODOCYTOPATHIES

60 Minimal Change Disease

A. Brad Farris, III, MD and Astrid Weins, MD, PhD

68 Classification of Focal Segmental Glomerulosclerosis

A. Brad Farris, III, MD and Astrid Weins, MD, PhD

72 Etiologic Classification of Focal Segmental

Glomerulosclerosis

Robert B. Colvin, MD

74 Focal Segmental Glomerulosclerosis, Primary

A. Brad Farris, III, MD and Astrid Weins, MD, PhD

82 Focal Segmental Glomerulosclerosis, Adaptive

(Secondary)

A. Brad Farris, III, MD and Astrid Weins, MD, PhD

88 Collapsing Glomerulopathy

A. Brad Farris, III, MD and Astrid Weins, MD, PhD

MEMBRANOUS NEPHROPATHY AND VARIANTS

98 Introduction to Membranous Nephropathy

Robert B. Colvin, MD

108 Etiologies of Membranous

Glomerulonephritis_Table

Robert B. Colvin, MD

110 Introduction to Membranous Nephropathy

Anthony Chang, MD

116 Mebranous Nephropathy Due to PLA2R

Autoantibodies

Anthony Chang, MD and Sanjeev Sethi, MD

120 Membranous Nephropathy Due to non-PLA2R

Antibodies

Anthony Chang, MD and Sanjeev Sethi, MD

124 Membranous Nephropathy Associated With

Systemic Disease

Anthony Chang, MD

128 Membranous Nephropathy With Organized Deposits

Anthony Chang, MD

132 Membranous Nephropathy With Anti-TBM

Antibodies

Robert B. Colvin, MD

134 Podocyte Infolding Glomerulopathy

Shane Meehan, MB, BCh

IGA-RELATED GLOMERULONEPHRITIS

136 Overview of IgA-Related Glomerular Diseases

Shane Meehan, MB, BCh

140 IgA Nephropathy

Lynn D. Cornell, MD, Robert B. Colvin, MD, and Ian Roberts, MBChB, FRCPath

154 IgA Vasculitis (Henoch-Schoenlein Purpura)

Anthony Chang, MD and Ian Roberts, MBChB, FRCPath

160 IgA Acute Glomerulonephritis Associated With

Staphylococcus aureus

Robert B. Colvin, MD and Ian Roberts, MBChB, FRCPath

164 Hepatic Disease With IgA Deposition

Robert B. Colvin, MD

SLE AND RELATED AUTOANTIBODYMEDIATED DISEASES

166 Systemic Lupus Erythematosus

Shane Meehan, MB, BCh, Robert B. Colvin, MD, and Ingeborg Bajema, MD

184 Mixed Connective Tissue Disease

A. Brad Farris, III, MD

186 Idiopathic Nonlupus Full-House Nephropathy

Ingeborg Bajema, MD and Emilie Rijnink, MD, PhD

188 Mixed Cryoglobulinemic Glomerulonephritis

A. Brad Farris, III, MD and Charles Alpers, MD

ANTI-GBM DISEASES

194 Anti-GBM Glomerulonephritis

Anthony Chang, MD

202 Atypical Anti-GBM Disease

Lynn D. Cornell, MD

COMPLEMENT-RELATED GLOMERULONEPHRITIS

206 Classification of MPGN and Complement-Related Diseases

Robert B. Colvin, Md 210 Dense Deposit Disease

A. Brad Farris, III, MD

216 C3 Glomerulonephritis

Lynn D. Cornell, MD

222 C1q Nephropathy

Neeraja Kambham, MD

228 C4 Glomerulopathy

Sanjeev Sethi, MD

232 MPGN With Immune Complexes

A. Brad Farris, III, MD, Jean Hou, MD, and Mark Haas, MD

MONOCLONAL IMMUNOGLOBULIN DISEASES OF GLOMERULI

240 Introduction to Diseases With Monoclonal

Immunoglobulin Deposits

Robert B. Colvin, MD

244 Monoclonal Immunoglobulin Deposition Disease

Lynn D. Cornell, MD

252 Proliferative Glomerulonephritis With Monoclonal

IgG Deposits

Lynn D. Cornell, MD

256 Membranous Glomerulonephritis With Masked IgG ?

Deposits

Christopher P. Larsen, MD and Tiffany Caza, MD

260 Type I Cryoglobulinemic Glomerulonephritis

Robert B. Colvin, MD and Evan Farkash, MD, PhD

264 Waldenstroem Macroglobulinemia

Anthony Chang, MD

266 Crystalglobulin Glomerulonephritis

Anthony Chang, MD and Mariam Priya Alexander, MD

AMYLOIDOSIS

270 Amyloidosis Classification

A. Brad Farris, III, MD and Sanjeev Sethi, MD

276 AL/AH Amyloidosis

A. Brad Farris, III, MD and Sanjeev Sethi, MD

282 AA Amyloidosis

A. Brad Farris, III, MD and Sanjeev Sethi, MD

286 AFib Amyloidosis

A. Brad Farris, III, MD and Sanjeev Sethi, MD

288 AGel Amyloidosis

Sanjeev Sethi, MD

290 ALECT2 Amyloidosis

Christopher P. Larsen, MD, Sanjeev Sethi, MD, and Tiffany Caza, MD

292 AApoAI Amyloidosis

A. Brad Farris, III, MD and Sanjeev Sethi, MD

293 AApoAII Amyloidosis

Robert B. Colvin, MD and Sanjeev Sethi, MD

294 AApoAIV Amyloidosis

Sanjeev Sethi, MD

295 AApoCII Amyloidosis

Sanjeev Sethi, MD

296 ATTR Amyloidosis

A. Brad Farris, III, MD and Sanjeev Sethi, MD

IDIOPATHIC FIBRILLARY GLOMERULOPATHIES

298 Diseases With Organized Deposits

Robert B. Colvin, MD

302 Fibrillary Glomerulopathy

Anthony Chang, MD

308 Immunotactoid Glomerulopathy

Anthony Chang, MD and Charles Alpers, MD

312 Fibronectin Glomerulopathy

Neeraja Kambham, MD

DIABETIC AND RELATED RENAL DISEASE

316 Diabetic Nephropathy

Neeraja Kambham, MD and Ian Roberts, MBChB, FRCPath

326 Metabolic Syndrome/Obesity-Related Glomerular Disease

Shane Meehan, MB, BCh

330 Idiopathic Nodular Glomerulopathy

A. Brad Farris, III, MD and Ian Roberts, MBChB, FRCPath

INFECTION-RELATED GLOMERULAR DISEASE

334 Overview of Infection-Related Glomerular Disease

Shane Meehan, MB, BCh

338 Acute Poststreptococcal Glomerulonephritis

A. Brad Farris, III, MD

346 Postinfectious Glomerulonephritis,

Nonstreptococcal

A. Brad Farris, III, MD

352 Glomerulonephritis of Chronic Infection, Including

Shunt Nephritis

A. Brad Farris, III, MD

354 Endocarditis

A. Brad Farris, III, MD and Christie L. Boils, MD

358 Syphilis

Shane Meehan, MB, BCh

360 Lyme Disease

Neeraja Kambham, MD

362 COVID-19 Nephropathies

Lynn D. Cornell, MD, Mariam Priya Alexander, MD, and Robert B. Colvin, MD

366 Hepatitis B Virus

Anthony Chang, MD

370 Hepatitis C Virus

Anthony Chang, MD and Charles Alpers, MD

376 Hepatitis B Virus

Anthony Chang, MD

380 HIV-Associated Nephropathy

A. Brad Farris, III, MD

386 Miscellaneous HIV-Associated Renal Diseases

A. Brad Farris, III, MD

392 Schistosomiasis

Neeraja Kambham, MD

394 Filariasis

Christie L. Boils, MD and Tiffany Caza, MD

395 Leishmaniasis

Kerstin Amann, MD and Robert B. Colvin, MD

DRUG-INDUCED GLOMERULAR DISEASES

396 Drug-Induced Minimal Change Disease

Anthony Chang, MD and Astrid Weins, MD, PhD

398 Bisphosphonate-Induced Collapsing Glomerulopathy

A. Brad Farris, III, MD and Astrid Weins, MD, PhD

399 Chloroquine Toxicity

Shane Meehan, MB, BCh

400 Antihepatitis C Virus Drugs

Ivy A. Rosales, MD

404 Anti-EGFR Drugs

Kammi J. Henriksen, MD

GENETIC DISEASES OF GLOMERULUS

406 Overview and Classification of Genetic Diseases of Glomerulus

Sanjay Jain, MD, PhD and Yasar Caliskan, MD

408 Genetic Causes of Nephrotic Syndrome

Joseph P. Gaut, MD, PhD

GENETIC DISEASES OF GLOMERULAR BASEMENT MEMBRANE COLLAGEN

412 Alport Syndrome

Joseph P. Gaut, MD, PhD, Helen Liapis, MD, and Robert B. Colvin, MD

424 Thin Basement Membrane Disease

Joseph P. Gaut, MD, PhD and Helen Liapis, MD

GENETIC DISEASES OF PODOCYTE

426 Diffuse Mesangial Sclerosis

Joseph P. Gaut, MD, PhD and Helen Liapis, MD

430 Congenital Nephrotic Syndrome of Finnish Type

Joseph P. Gaut, MD, PhD and Helen Liapis, MD

434 Pierson Syndrome

Joseph P. Gaut, MD, PhD and Helen Liapis, MD

436 Galloway-Mowat Syndrome

Stephen M. Bonsib, MD

438 Denys-Drash Syndrome

Kammi J. Henriksen, MD and Stephen M. Bonsib, MD

442 Frasier Syndrome

Stephen M. Bonsib, MD

446 Podocin Deficiency

Joseph P. Gaut, MD, PhD and Helen Liapis, MD

448 a-Actinin-4 Deficiency

Joseph P. Gaut, MD, PhD and Helen Liapis, MD

450 Autosomal Dominant FSGS Due To INF2 Mutations

Robert B. Colvin, MD

452 APOL1-Related Glomerular Disease

Christopher P. Larsen, MD and Tiffany Caza, MD

456 Schimke Immunoosseous Dysplasia

Shane Meehan, MB, BCh

GENETIC STORAGE AND LIPID DISEASES

458 Fabry Disease

Robert B. Colvin, MD and Laura Barisoni, MD

466 Alagille Syndrome

Anthony Chang, MD

468 Lecithin Cholesterol Acyltransferase Deficiency

Carrie L. Phillips, MD and Stephen M. Bonsib, MD

472 APOE Lipoprotein Glomerulopathy

Joseph P. Gaut, MD, PhD and Helen Liapis, MD

474 Type III Hyperlipoproteinemia

Joseph P. Gaut, MD, PhD and Helen Liapis, MD

476 I-Cell Disease (Mucolipidosis II)

Stephen M. Bonsib, MD

478 Gaucher Glomerulopathy

A. Brad Farris, III, MD

OTHER GENETIC DISEASES AFFECTING GLOMERULUS

480 Type III Collagen Glomerulopathy

Joseph P. Gaut, MD, PhD, L. Nicholas Cossey, MD, FCAP, and Helen Liapis, MD

484 Nail-Patella Syndrome

Joseph P. Gaut, MD, PhD and Helen Liapis, MD

486 Glomerulopathy of Hereditary Multiple Exostoses

Robert B. Colvin, MD and Ian Roberts, MBChB, FRCPath

MISCELLANEOUS GLOMERULAR DISEASES

488 Cryofibrinogenic Glomerulopathy

Lynn D. Cornell, MD and Mariam Priya Alexander, MD

492 IgM Nephropathy

Neeraja Kambham, MD

494 IgG Nephropathy

Anthony Chang, MD

498 Vaccination-Associated Renal Disease

Astrid Weins, MD, PhD and Mariam Priya Alexander, MD

502 Nephropathies in Chronic Liver Diesease, Including Hepatic Glomerulosclerosis

Robert B. Colvin, MD

506 Renal Disease in Rheumatoid Arthritis

Neeraja Kambham, MD

512 Hemophagocytic Glomerulopathy

Lynn D. Cornell, MD

516 Coenzyme-Q Nephropathies

Laura Barisoni, MD

520 Intravascular Large B-Cell Lymphoma

Anthony Chang, MD

SECTION 3: VASCULAR DISEASES

524 Overview and Classification of Systemic Vasculitides

Surya V. Seshan, MD and Ingeborg Bajema, MD

ANCA DISEASES

534 ANCA-Related Glomerulonephritis

Surya V. Seshan, MD and Ingeborg Bajema, MD

540 Microscopic Polyangiitis

Surya V. Seshan, MD and Ingeborg Bajema, MD

548 Granulomatosis With Polyangiitis

Surya V. Seshan, MD and Ingeborg Bajema, MD

558 Eosinophilic Granulomatosis With Polyangiitis

(Churg-Strauss)

Surya V. Seshan, MD and Ingeborg Bajema, MD

564 Drug-Induced ANCA Vasculitis

Surya V. Seshan, MD and Ingeborg Bajema, MD

NON-ANCA VASCULITIDES

568 Polyarteritis Nodosa

Surya V. Seshan, MD

574 Kawasaki Disease

Surya V. Seshan, MD and Yael K Heher, MD

576 Giant Cell Arteritis

Surya V. Seshan, MD

580 Takayasu Arteritis