Main description:

Stroke is the leading cause of neurological morbidity and mortality and the third leading cause of mortality worldwide. In spite of several advances over the past two decades in acute stroke management, stroke prevention and neuroprotection, there is no clear consensus in any of the areas of diagnosis and management. The complex interplay between treatment modalities and the individual patient makes each case quite unique and physicians need to walk the tightrope of balancing the subtle and complicated see-saw of evidence and experience-based medicine. This book has contributions by a group of internationally recognized experts who have written extensively on strategies of 'thinking out of the box while not discarding the current evidence'. The authors have taken their expertise and experience into account while formulating the best practice recommendations fully recognizing that guidelines fall short and there is a continued need to synthesize current best practice opinion with individualized medicine. This book offers a rational approach to the current diagnosis and treatment of stroke that individual physicians can apply to their practice.

Contents:

Foreword; Preface; Acknowledgements; Contributors; Abbreviations; 1. Personalized medicine - What is it? Is it worthwhile? Can it be continued in an era dominated by managed care and 'evidence-based medicine'? - Louis R. Caplan; 2. Imaging the ischaemic penumbra: Ready for prime time in clinical trials and practice - Marc Fisher; 3. Neuroprotection in ischaemic stroke - Monica Saini, Ashfaq Shuaib; 4. Thrombolysis for acute ischaemic stroke: Are off-label indications justified? - M.V.Padma Srivastava; 5. Antihypertensive medications in stroke: Controversies and recommendations - M.V. Padma Srivastava, Majaz Moonis; 6. Intra-arterial interventions within the 3-hour window after acute ischaemic stroke - Majaz Moonis; 7. Controversies in the management of intracerebral haemorrhage - Magdy Selim; 8. Do all stroke patients need to be evaluated for CAD? - Rohit Bhatia, Abhishek Singh; 9. Acute high-dose statins improve stroke outcome: Myth or reality? - Nils Henninger; 10. Cervicocerebral arterial dissection - Monica Saini, Ashfaq Shuaib; 11. Prevention of deep vein thrombosis in patients with acute stroke - Jeyaraj D. Pandian; 12. Antiepileptic drug prophylaxis for seizures in cerebrovascular accidents - Jayashree T. Narayanan; 13. Antiplatelet drugs: Does it make a difference which one you use? - Fernando D. Testai, Philip B. Gorelick; 14. Cerebral venous thrombosis - Rohit Bhatia; 15. Non-convulsive status and EEG monitoring in the neuro-ICU - Jaishree T. Narayanan; 16. Evaluation for hypercoagulable states: Special reference to venous and arterial thrombosis - M.V. Padma Srivastava; 17. Role of infections in stroke: How true is the association? - Subhash Kaul, V.C.S. Srinivasarao Bandaru; 18. Relationship between migraine and stroke: How true and how close? - M.V. Padma Srivastava; 19. Prevention of ischaemic stroke: Carotid revascularization - Kumar Rajamani, Seemant Chaturvedi; 20. Are Alzheimer dementia (AD) and vascular dementia (VAD), different clinical profiles of the same disease spectrum?: Defining the common markers - M.V. Padma Srivastava; 21. Restorative therapy in stroke: Is there a role for stem cells? - M.V. Padma Srivastava, Ashi Bhasin; 22. Controversies in telemedicine - Pratik Bhattacharya, Ramesh Madhavan; 23. Stroke in the young: Does the aetiology and prognosis differ from stroke in older patients - Man Mohan Mehndiratta, Tarun Vijay, Prachi Mehndiratta; 24. Obstructive sleep aponea and stroke - Mamta Bhushan Singh; Index.