Main description:

Caroline Hebert and a panel of key experimentalists and clinical investigators comprehensively review the state-of-the-art in the chemokine field, ranging from the effects of chemokines and their receptors in retroviral infections, to their role in inflammation, angiogenesis/angiostasis, and tumor cell biology. The book examines in detail fifteen recently identified chemokines and elucidates the role of chemokine function in vivo from animal experiments. Animal models are also used to explore how chemokines operate in a variety of chronic and acute inflammatory diseases and in noninflammatory processes. A detailed review of the emerging role of chemokines in viral biology is also presented, with emphasis on HIV biology and novel therapeutic possibilities. Chemokines in Disease: Biology and Clinical Research summarizes the rapidly expanding knowledge of a dazzling array of chemokines and provides fresh insights into the development of powerful new drugs for treating a wide spectrum of diseases.

Contents:

Part I: Novel Chemokines Discovery and Genetically Engineered Mice. The Chemokine Gene Family: Similar Structures, Diverse Functions, Vicki L. Schweickart, Carol J. Raport, David Chantry, and Patrick W. Gray. Novel Chemokines Identified in Expressed Sequence Tag Databases via Bioinformatics, Kuldeep S. Neote and Shaun R. McColl. Understanding Chemokine Biology Through Mouse Genetics: Riddles and Answers, Craig Gerard. MCP-1 in Human Disease: Insights Gained from Animal Models, Landin Boring, Israel F. Charo, and Barrett J. Rollins. Part II: Chemokines in Inflammatory Disease. IL-8 in Animal Models of Disease, Akihisa Harada and Kouji Matsushima. The Role of Chemokines in the Pathophysiology of the Acute Respiratory Distress Syndrome (ARDS), Thomas R. Martin and Richard B. Goodman. The Role of Chemokines in Allergic Airway Inflammation, Nicholas W. Lukacs. Eotaxin in Disease, Dolores M. Conroy and Timothy J. Williams. The Role of CC Chemokines in Th1- and Th2-Type Pulmonary Inflammation Models, Cory M. Hogaboam, Stephen W. Chensue, and Steven L. Kunkel. Chemokines in Rheumatoid Arthritis, Christine Plater-Zyberk, Jiri Vencovsky, and Christine A. Power. Potential Roles for Chemokines in Transplant Rejection, Ronald P. Gladue and Thomas M. Coffman. Part III: Chemokines in Tumor Biology. The Role of CXC Chemokines in the Regulation of Angiogenesis in Association with Non-Small-Cell Lung Cancer, Robert M. Strieter, Christina L. Addison, Bethany B. Moore, and Douglas A. Arenberg. The Role of ELR+-CXC Chemokines in Wound Healing and Melanoma Biology, Ann Richmond, Jing Luan, Jianguo Du, and Hamid Haghnegahdar. Engineering, Biology, and Clinical Development of hMIP-1a, Lloyd G. Czaplewski, Matthew McCourt, Michael G. Hunter, Brian I. Lord, Andy Millar, and L. Mike Wood. Part IV: Chemokines in Viral Biology. Viral Mimicry of Chemokines and Chemokine Receptors, Sunil K. Ahuja and Philip M. Murphy. The HIV Coreceptor Repertoire: All in the Family of Chemokine Receptors, EdwardA. Berger and Joshua M. Farber. HIV-1 Coreceptors and Viral Tropism, Robert W. Doms and John P. Moore. Mutation Analysis of Receptors and Relationship of Receptor Usage to Disease, Emma J. Aarons and Richard A. Koup. Chemokines and Chemokine Receptors in the Brain: Function in the Normal and Pathophysiologic CNS, Joseph Hesselgesser and Richard Horuk. Antagonism of Chemokine Receptors in Preventing Infection by HIV, Amanda E. I. Proudfoot and Timothy N. C. Wells. Index.