Main description:

Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.

Contents:

Part I. Cytokine Knockouts in Models of Human Disease

Cytokine Knockouts in Inflammation
Pietro Ghezzi

The Use of Cytokine Knockouts to Study Host Defense Against Infection
Charles A. Dinarello

The Use of Cytokine Knockouts in Animal Models of Autoimmune Disease
Alfons Billiau, Hubertine Heremans, and Patrick Matthys

The Use of Cytokine Knockout Mice in Cancer Research
Robert H. Wiltrout, Jon M. Wigginton, and William J. Murphy

The Use of Cytokine Knockout Mice in Neuroimmunology
Giamal N. Luheshi, Emmanuel Pinteaux, and Herve Boutin

Part II. Cytokine Knockout Mice

The Role of IL-1 in the Immune System
Susumu Nakae, Reiko Horai, Yutaka Komiyama, Aya Nambu, Masahide Asano, Akio Nakane, and Yoichiro Iwakura

IL-1 Receptor Antagonist-Deficient Mice
Martin J. H. Nicklin and Joanna Shepherd

A Unique Role for IL-2 in Self-Tolerance
Thomas Hunig and Anneliese Schimpl

Molecular Basis for Binding Multiple Cytokines by gc: Implications for X-SCID and Impaired gc-Dependent Cytokine Receptor Function
Ferenc Olosz and Thomas R. Malek

G-CSF, GM-CSF, and IL-3 Knockout Mice
Thomas Enzler and Glenn Dranoff

IL-4 Knockout Mice
Pascale Kropf and Ingrid Muller

Role of IL-5 in Immune and Pathological Responses in the Mouse
Paul S. Foster and Simon P. Hogan. IL-6 Knockout Mice, Valeria Poli and Diego Maritano

IL-10 and IL-2 Knockout Mice: Effect on Intestinal Inflammation
Karen L. Madsen and Humberto Jijon

IL-12-Deficient Mice
Luciano Adorini

IL-13 and Double IL-4/IL-13 Knockout Mice
Duncan R. Hewett and Andrew N. J. McKenzie

IL-15: Insights from Characterizing IL-15-Deficient Mice
Pallavur V. Sivakumar, Sandra N. Brown, Ananda W. Goldrath, Anne Renee Van der Vuurst de Vries, Joanne L. Viney, and Mary K.Kennedy

IL-18 and IL-18 Receptor Knockout Mice
Hiroko Tsutsui, Tomohiro Yoshimoto, Haruki Okamura, Shizuo Akira, and Kenji Nakanishi

Mice Knockouts for Chemokines and Chemokine Receptors
Jane M. Schuh, Steven L. Kunkel, and Cory M. Hogaboam

IFN-g and IFN-g Receptor Knockout Mice, Dyana Dalton

Macrophage Migration Inhibitory Factor (MIF)-Deficient Mice
Gunter Fingerle-Rowson, Abhay R. Satoskar, Richard Bucala

Osteopontin, a Surprisingly Flexible Cytokine: Functions Revealed from Osteopontin Knockout Mice
Susan R. Rittling, Anthony W. O'Regan, and Jeffrey S. Berman

RANKL, RANK, and OPG
Young-Yun Kong and Josef M. Penninger

Targeting the TGF-b Pathway In Vivo: Defining Complex Roles for TGF-b Signaling in Immune Function, Wound Healing, and Carcinogenesis
Lawrence Wolfraim, Mizuko Mamura, Anita Roberts, and John J. Letterio

Physiologic Roles of Members of the TNF and TNF Receptor Families as Revealed by Knockout Models
Sergei A. Nedospasov, Sergei I. Grivennikov, and Dmitry V. Kuprash

Index