Main description:

This book makes available, for interested scientists to procure, absorb, and evaluate, the vast body of information on the research and results of the work on the chemistry of penicillin done in England and the United States during the war. The National Academy of Sciences arranged for the preparation of this summary, Dr. H. T. Clarke and Dr. J. R. Johnson representing the United States on the editorial board, and Sir Robert Robinson representing Britain. The body of the work was prepared by more than 60 outstanding biochemists and biophysicists, who describe the phases of research to which they contributed the most. The work of 23 academic, medical, industrial, and government laboratories is reported. Originally published in 1949. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions.
The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Contents:

*Frontmatter, pg. i*Preface, pg. v*Contents, pg. ix*I. Brief History of the Chemical Study of Penicillin, pg. 1*II. The Earlier Investigations relating to 2-Pentenylpenicillin, pg. 10*III. The Chemistry of n-Amylpenicillin up to December 1943, pg. 38*IV. Status of the Research on the Structure of Benzylpenicillin in December 1943, pg. 52*V. Isolation and Characterization of the Various Penicillins, pg. 76*VI. Penillic Acids and Penillamines, pg. 106*VII. Review of Certain Investigations on the Structure of Benzylpenicillin during 1944-1945, pg. 144*VIII. Some Inactivation and Degradation Reactions not included in Chapters IV and VII, pg. 207*IX. Desthiobenzylpenicillin and Other Hydrogenolysis Products of Benzylpenicillin, pg. 243*X. The Thiocyanate Derivative of Benzylpenicillin Methyl Ester, pg. 269*XI. The X-Ray Crystallographic Investigation of the Structure of Penicillin, pg. 310*XII. Identification and Crystallography of Penicillins and Related Compounds by X-Ray Diffraction Methods, pg. 367*XIII. Infrared Spectroscopic Studies on the Structure of Penicillin, pg. 382*XIV. Other Physical Methods, pg. 415*XV. The Constitution of Penicillins, pg. 440*XVI. Penicillamine, Its Analogs and Homologs, pg. 455*XVII. Penilloaldehydes and Penaldic Acids, pg. 473*XVIII. The Penilloic and Penicilloic Acids and Their Derivatives and Analogs, pg. 535*XIX. Biosynthesis of Penicillins, pg. 657*XX. Chemical Modifications of Natural Penicillins, pg. 680*XXI. Oxazoles and Oxazolones, pg. 688*XXII. Attempted Syntheses of Penicillins, pg. 849*XXIII. The Condensation of Oxazolones and D-Penicillamine and the Resultant Antibiotic Activity, pg. 892*XXIV. Methyl Benzylpseudopenicillinate, pg. 909*XXV. Thiazolidines, pg. 921*XXVI. The Chemistry of ss-Lactams, pg. 973*XXVII. The gamma-Lactam of Benzylhomopenicilloic Acid and Related Compounds, pg. 1004*XXVIII. Synthetic Benzylpenicillin, pg. 1018*XXIX. Assay of Penicillins, pg. 1025*XXX. Appendix, pg. 1043*SUBJECT INDEX, pg. 1069