Main description:

This book presents the latest advances in the field of regenerative medicine in plastic surgery. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner.The first part introduces readers to essential principles of skin and soft tissue regeneration, e.g. the possibility of using mesenchymal stem cells for wound healing. Since bone serves as a supportive tissue in most of the body, bone regeneration is an important aspect of regenerative medicine; accordingly, the second part discusses the novel bone implants, activated bone grafts and bone tissue engineering. The book's third part, focusing on cartilage regeneration, includes chapters on e.g. stem cells and ear regeneration. In turn, part four addresses muscle and tendon regeneration: from tendon to bone and tendon to muscle, as well as aging in the realm of muscle regeneration. Lastly, part five highlights nerve regeneration, deepening surgeons' knowledge to help them successfully treat injuries to the peripheral neural system. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties.

"With beautiful clinical images and artwork, this book will be a central companion to both practicing plastic surgeons who wish to remain abreast of oncoming technologic advances and regenerative medicine researchers who wish to understand the current state of the art of surgical reconstruction."
- Geoffrey C. Gurtner, MD, FACS
Johnson and Johnson Distinguished Professor of Surgery
Professor (by courtesy) of Bioengineering and Materials Science
Inaugural Vice Chairman of Surgery for Innovation
Stanford University School of Medicine

Contents:

PART 1: SKIN AND SOFT TISSUE REGENERATION1. Induction of the Fetal Scarless Phenotype in Adult Wounds: Impossible?2. Scar Treatment and Prevention: Know Thine Enemy3. Challenges and Opportunities in Drug Delivery and Wound Healing4. Harvesting, Processing and Injection of Lipoaspirate for Soft Tissue Reconstruction - Details Make the Difference5. Adipose Tissue Complex (ATC): Cellular & Biocellular Uses of Stem/Stromal Cells & Matrix in Cosmetic Plastic, Reconstructive Surgery & Regenerative Medicine6. Preparation, Characterization, and Clinical Implications of Human Decellularized Adipose Tissue Extracellular Matrix7. Mesenchymal Cells that Support Human Skin Regeneration8. Stem Cells and Burn9. Skin Tissue Engineering Advances in Severe Burns: Review and Therapeutic Applications10. Skin Substitutes for Burn Wounds11. Wnt Signaling During Cutaneous Wound Healing12. Drug Delivery Advances for the Regeneration of Aged SkinPART 2: BONE REGENERATION13. Innovative Scaffold Solution for Bone Regeneration Made of Beta-Tricalcium Phosphate Granules, Autologous Fibrin Fold and Peripheral Blood Stem Cells14. Ordinary and Activated Bone Substitutes15. Absorbable Bone Substitute Materials Based on Calcium Sulfate as Triggers for Osteoinduction and Osteoconduction16. Perivascular Progenitor Cells for Bone Regeneration17. Bone Repair and Regeneration is Regulated by the Wnt Signaling PathwayPART 3: CARTILAGE REGENERATION18. Cartilage Tissue Engineering: Role of Mesenchymal Stem Cells, Growth Factors and Scaffolds19. Sox9 Potentiates BMP2-induced Chondrogenic Differentiation and Inhibits BMP2-induced Osteogenic Differentiation20. Stem Cells and Ear RegenerationPART 4: MUSCLE AND TENDON REGENERATION21. Muscle Fiber Regeneration in Long Term Denervated Muscles. Basics and Clinical Perspectives22. Rejuvenating Stem Cells to Restore Muscle Regeneration in Aging23. Silk Fibroin-Decorin Engineered Biologics to Repair Musculofascial Defects24. Skeletal Muscle Restoration Following Volumetric Muscle Loss: the Therapeutic Effects of a Biologic Surgical Mesh25. Principles of Tendon Regeneration26. Stem Cells and Tendon Regeneration27. Cell Therapies for Tendon: Treatments and Regenerative MedicinePART 5: NERVE REGENERATION28. The present and future for peripheral nerve regeneration29. The Regeneration of Peripheral Nerves Depends on Repair Schwann Cells30. Adipose-derived Stem Cells (ASCs) for Peripheral Nerve Regeneration31. Direct Reprogramming Somatic Cells into Functional Neurons: A New Approach to Engineering Neural Tissue in Vitro and in Vivo