Main description:

This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner.
Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery.
Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties.

"In your hands is a comprehensive encyclopedia of two rapidly converging fields. Drs Duscher and Shiffman have done an outstanding job of highlighting the interdependent relationship between plastic surgery and regenerative medicine. Ultimately, this is to the benefit of both fields."
- Geoffrey C. Gurtner, MD, FACS
Johnson and Johnson Distinguished Professor of Surgery
Professor (by courtesy) of Bioengineering and Materials Science
Inaugural Vice Chairman of Surgery for Innovation
Stanford University School of Medicine

Contents:

Part I - ELEMENTS OF REGENERATIVE MEDICINE1. Definitions2. History of Regenerative Medicine3. Basic Principles and Current Approach for Soft Tissue Regeneration4. Sophisticated Biocomposite Scaffolds from Renewable Biomaterials for Bone Tissue EngineeringPart II - RESEARCH CONCEPTS5. Mechanotransduction in wound healing and scar formation6. Stromal Cell-Derived Factor1 (SDF-1) Signaling and Tissue Homeostasis7. Stem Cell Differentiation Directed by Material and Mechanical Cues8. Bacteriophages: a New (Yet Old) Weapon against Infections9. Bacteriophages as Biocontrol Agents of Biofilm Infections Associated with Abiotic Prosthetic Devices10. Extracellular vesicles derived from Mesenchymal Stem/Stromal Cells: Current Approaches to Enhance Their Release and Therapeutic Potential11. Anti-Biofilm Activity of Viruses, Bacteria, Fungi and Lichens: Mechanisms and Impact on Clinical PracticePart III - EMERGING TECHNOLOGIES12. Bionic Reconstruction: The New Frontier13. Carbohydrates in Regenerative Medicine: From Scaffolds to Cell Fate Modulators14. Biomimetics: A New Abstraction for Bone Implant Design15. The Role of Microbiota in Skin Regeneration16. Erythropoietin: An Innovative Therapeutic Approach in Thermal Trauma17. Targeting C-Reactive Protein in Inflammatory Disease18. Stem Cell Therapies for Tissue Regeneration and Wound Healing: Strategies to Enhance Therapeutic Effectiveness19. Iron Chelators & HIF-1 : A new Frontier for Skin RejuvenationPart IV - TRANSLATIONAL ASPECTS20. How to Overcome the Valley of Death from Basic Science to Clinical Trials21. Moving Your Results from Bench to Bedside: Protecting Scientific Findings22. The Regulatory Landscape of Cell- and Tissue-Based Regenerative Medicine: Current Challenges and Emerging Issues23. Translational Challenges in Soft Tissue Regeneration24. Bone Tissue Engineering Challenges in Craniofacial Reconstructive Surgeries25. Translational Challenges: Lymph Node Tissue Engineering26. Implementing Tissue Engineering and Regenerative Medicine Solutions in Silicone ImplantsPart V - REGENERATIVE PLASTIC SURGERY27. Microdeformational Wound Therapy28. Clinical Treatment of Hypertrophic Scars29. Tissue Engineering and Regenerative Medicine in Oral and Maxillofacial Surgery: The Most Important Clinical Applications of Mesenchymal Stem Cells30. Reconstruction of Post-Traumatic Maxillary Ridges Using a Radial Forearm Free Flap and Allogeneic Tissue Engineered Bone Grafts31. Postoperative Complications of Mandibular Fracture Management32. Use of Porcine Urinary Bladder Matrix (UBM-ECM) in the Head and Neck Region33. Advances in Facial Nerve Paralysis: Surgical Innovation, Tissue Engineering, and Emerging Technology34. Management of Capsular Contracture: Non- Surgical and Surgical Options35. Soft Tissue Reconstruction of the Lower Limb