Schizophrenia may not be a single disease, but the result of a diverse set of related conditions. Modern neuroscience is beginning to reveal some of the genetic and environmental underpinnings of schizophrenia; however, an approach less well travelled is to examine the medical disorders that produce symptoms resembling schizophrenia. This book is the first major attempt to bring together the diseases that produce what has been termed 'secondary schizophrenia'. International experts from diverse backgrounds ask the questions: does this medical disorder, or drug, or condition cause psychosis? If yes, does it resemble schizophrenia? What mechanisms form the basis of this relationship? What implications does this understanding have for aetiology and treatment? The answers are a feast for clinicians and researchers of psychosis and schizophrenia. They mark the next step in trying to meet the most important challenge to modern neuroscience – understanding and conquering this most mysterious of human diseases.
Part I. Introduction: 1. The neurobiology and aetiology of primary schizophrenia: current status Matcheri S. Keshavan and Ripu D. Jindal; 2. The concept of organicity and its application to schizophrenia Perminder S. Sachdev; 3. Secondary hallucinations Mark Walterfang, Ramon Mocellin, David Copolov and Dennis Velakoulis; Part II. The Neurology of Schizophrenia: 4. The neurologic examination in schizophrenia Richard D. Sanders and Matcheri S. Keshavan; 5. Functional neuroimaging in schizophrenia Serge A. Mitelman, Jane Zhang and Monte S. Buchsbaum; Part III. Organic Syndromes of Schizophrenia; Section 1. Epilepsy and Schizophrenia: 6. Schizophrenia-like psychosis and epilepsy Perminder S. Sachdev; 7. Understanding the pathophysiology of schizophrenia through the looking glass of forced normalization Ennapadam S. Krishnamoorthy and Seethalakshmi Ramanathan; Section 2. Drugs and Schizophrenia-like Psychosis: 8. Substance-induced psychosis: an overview Jagadisha Thirthalli, Vivek Benegal and Bangalore N. Gangadhar; 9. Stimulants and psychosis Nash N. Boutros, Matt Galloway and Eric M. Pihlgren; 10. The psychotomimetic effects of PCP, LSD and Ecstasy: pharmacological models of schizophrenia? Vibeke S. Catts and Stanley V. Catts; 11. Schizophrenia secondary to cannabis use Wayne Hall and Louisa Degenhardt; 12. Toxic psychosis Rajeev Kumar and Jeffrey C. L. Looi; Section 3. Other Neurological Disorders: 13. Schizophrenia-like psychosis and traumatic brain injury (TBI) Perminder S. Sachdev; 14. Cerebrovascular disease and psychosis Osvaldo P. Almeida and Sergio E. Starkstein; 15. Neurodegenerative disorders (Alzheimer's disease, frontotemporal dementia) and schizophrenia-like psychosis Nicola T. Lautenschlager and Alexander F. Kurz; 16. Storage disorders and psychosis Mark Walterfang and Dennis Velakoulis; 17. Mitochondrial disorders and psychosis Dennis Velakoulis and Mark Walterfang; 18. Psychosis associated with leukodystrophies Patricia I. Rosebush, Rebecca Anglin and Michael Mazurek; 19. Normal pressure hydrocephalus Julian Trollor; 20. Brain tumours Malcolm Hopwood and Lyn-May Lim; 21. Demyelinating disease and psychosis Anthony Feinstein; Section 4. Systemic Disorders: 22. Infection and schizophrenia Alan S. Brown and Ezra S. Susser; Section 5. Genetic Disorders Related to SLP: 23. The status of genetic investigations of schizophrenia Bryan Mowry; 24. Velocardiofacial Syndrome (Chromosome 22q11.2 Deletion Syndrome) as a model of schizophrenia Vandana Shashi and Margaret N. Berry; 25. Psychosis in Prader-Willi Syndrome Stewart L. Einfeld, Sophie Kavanagh, Arabella Smith and Bruce J. Tonge; 26. Friedrich's Ataxia and schizophrenia-type psychosis Perminder S. Sachdev; 27. Wilson's disease Edward C. Lauterbach and Leslie Lester-Burns; 28. Huntington's disease and related disorders and their association with schizophrenia-like psychosis Perminder S. Sachdev; 29. Fahr's disease and psychosis Kim Burns and Henry Brodaty; Part IV. Related Concepts: 30. The Charles Bonnet Syndrome William Burke; 31. Acute brief psychosis – an organic syndrome? Anand K. Pandurangi; Part V. Treatment: 32. Drug treatment of secondary schizophrenia Michael D. Jibson and Rajiv Tandon; 33. Non-pharmacological interventions in secondary schizophrenia David J. Kavanagh, Jennifer M. Connolly and Kim T. Mueser.