Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control. Part One of the book provides general coverage of nutrition and diabetes in terms of dietary patterns, insulin resistance, and the glucose-insulin axis, while Part Two presents the molecular biology of diabetes and focuses on areas such as oxidative stress, mitochondrial function, insulin resistance, high-fat diets, nutriceuticals, and lipid accumulation. Final sections explore the genetic machinery behind diabetes and diabetic metabolism, including signaling pathways, gene expression, genome-wide association studies, and specific gene expression. While the main focus of each chapter is the basic and clinical research on diabetes as a nutritional problem, all chapters also end with a translational section on the implications for the nutritional control of diabetes.
Section 1: General and Introductory Aspects 1. Nutrition and diabetes: general aspects Ana M. Wagner, Julia Charlotte Wiebe, Rosa M. Sanchez-Hernandez and Lidia Garcia-Perez 2. Dietary patterns and insulin resistance Marcio A. Torsoni, Adriana Souza Torsoni and Marciane Milanski 3. Beta cell metabolism, insulin production and secretion; metabolic failure resulting in diabetes Younan Chen, Vinicius Fernandes Cruzat and Philip Newsholme 4. Diet-gene interactions in the development of diabetes Jose M. Ordovas 5. Pathogenesis of type 1 diabetes: role of dietary factors Julie Christine Antvorskov, Karsten Buschard and Knud Josefsen Section 2: Molecular biology of the cell 6. Oxidative stress in diabetes mellitus: molecular aspects: implications for the diet Lu Cai 7. Muscle protein in type 2 diabetes: Molecular aspects Antonio Zorzano 8. Mechanisms whereby wholegrain cereals modulate the prevention of type-2 diabetes Knud Erik Bach Knudsen, Kjeld Hermansen, Mette Skou Hedemann and Merete Lindberg Hartvigsen 9. Peroxisome proliferator activated receptors -PPARs - in glucose control Massimo Collino and Fausto Chiazza 10. High-fat diets and beta-cell dysfunction: molecular aspects Carla B. Collares-Buzato 11. Native fruits, anthocyanins in nutraceuticals and the insulin receptor/insulin receptor substrate-1/Akt/ forkhead box protein pathway N.R.V. Dragano and Anne y Castro Marques 12. Influence of dietary factors on gut microbiota: role on insulin resistance and diabetes mellitus Gemma Xifra Villarroya, Eduardo Esteve and J.M Fernandez-Real 13. Molecular aspects of Glucose regulation of pancreatic beta-cells Rosa Gasa, Ramon Gomis, Anna Novials and Joan-Marc Servitja 14. Metals and signalling in diabetes Lu Cai 15. Cocoa flavonoids and insulin signalling Sonia Ramos, M.A. Martin and Luis Goya 16. Dietary proanthocyanidin modulation of pancreatic beta-cells: molecular aspects Montserrat Pinent, Mayte Blay, Anna Ardevol and Noemi Gonzalez-Abuin 17. Dietary whey protein and Type 2 diabetes: molecular aspects Jaime Amaya-Farfan, Priscila Neder Morato, Carolina Soares Moura and Pablo Lollo 18. Dietary fatty acids and C-reactive proteins in diabetes Giovanni Annuzzi, Ettore Griffo, Giuseppina Costabile and Lutgarda Bozzetto 19. Alcoholic beverage and diabetes: cellular and molecular effects Suzanne de la Monte Section 3: Genetic machinery and its function 20. Alleles and risk of diabetes Valeriya Lyssenko 21. Micro RNAs in diabetes Louise Torp Dalgaard, Sofia Anna Salo, Anja Elaine Sorensen and Julian Geiger 22. Diabetes mellitus and intestinal Niemann-Pick C1-Like1 gene expression W. A. Alrefai, Pooja Malhotra, Ravinder K. Gill and Pradeep K. Dudeja 23. Dietary long-chain omega-3 polyunsaturated fatty acids and inflammatory gene expression in type 2 diabetes Manohar Lal Garg 24. Polymorphisms, carbohydrates, fat and type 2 diabetes: the example of insulin receptor substrate 1 (IRS1) Jose Lopez-Miranda 25. Genetic basis linking variants for diabetes and obesity with breast cancer Vijay Kumar Kutala 26. Genetic determinants of pathways underlying 25(OH) vitamin D deficiency predisposing to type 1 and type 2 diabetes mellitus Dharambir K. Sanghera and Piers R. Blackett 27. NRF2-mediated gene regulation and glucose homeostasis Masayuki Yamamoto and Akira Uruno 28. Hepatic mitochondrial fatty acid oxidation and type 2 diabetes Abdelhak Mansouri, Wolfgang Langhans, Jean Girard and Carina Prip-Buus 29. The wnt signaling pathway and glucose homeostasis T. Jin