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Host-Pathogen Interactions in Streptococcal Diseases
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Main description:

Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae. Antibiotics alone have not been able to control the disease and in spite of many efforts an effective vaccine is not yet available. A prerequisite for novel and successful strategies for combating these bacteria is a complete understanding of the highly complex pathogenic mechanisms involved, which are analyzed in this volume. In ten chapters, prominent authors cover various aspects including streptococcal diseases and global burden, epidemiology, adaptation and transmission, and molecular mechanisms of different diseases, as well as sequelae, vaccine development and clinical management. This book will serve as a valuable reference work for scientists, students, clinicians and public health workers and provide new approaches to meeting the challenge of streptococcal diseases.


A useful reference work for everyone working in the field of streptococcal infections and their sequelae

Provides an up-to-date and comprehensive overview  ​

Written by leading authorities in the subject area


Group A Streptococcal Diseases and Their Global Burden

Anna P. Ralph and Jonathan R Carapetis


Molecular Markers for the Study of Streptococcal Epidemiology

David J McMillan, Martina L Sanderson-Smith, Pierre Smeesters and Kadaba S Sriprakash


Epidemiology and Pathogenicity of Zoonotic Streptococci

Marcus Fulde and Peter Valentin-Weigand


Adherence and Invasion of Streptococci to Eukaryotic Cells and Their Role

in Disease Pathogenesis

Manfred Rohde and G. Singh Chhatwal


Common Regulators of Virulence in Streptococci

Nadja Patenge, Tomas Fiedler and Bernd Kreikemeyer


Host-Pathogen Interactions in Streptococcal Immune Sequelae

D. Patric Nitsche-Schmitz and Gursharan S. Chhatwal


Immunopathogenesis of Streptococcal Deep Tissue Infections

Linda Johansson and Anna Norrby-Teglund


Modulation of the Coagulation System During Severe Streptococcal Disease

Oonagh Shannon, Heiko Herwald and Sonja Oehmcke


Group A Streptococcal Vaccine Candidates: Potential for the Development of a Human Vaccine

Anna Henningham, Christine M. Gillen and Mark J. Walker


Clinical Management of the Most Common Group A β-Hemolytic Streptococcal Infections

Edward Kaplan


ISBN-13: 9783642363405
Publisher: Springer (Springer Berlin Heidelberg)
Publication date: March, 2013
Pages: 300

Subcategories: General Issues, Immunology, Microbiology, Public Health