Books on bioinformatics which began appearing in the mid 80s primarily served gene-hunters, and biologists who wished to construct family trees showing tidy lines of descent. Given the great pharmaceutical industry interest in genes, this trend has continued in most subsequent texts. These deal extensively with the exciting topic of gene discovery and searching databases, but hardly consider genomes as information channels through which multiple forms and levels of information, including genic information, have passed through the generations.
This book identifies the types of information that genomes transmit and it shows how competition between different types is resolved in the genomes of different organisms
The book is unique in emphasising non-genic aspects of bioinformatics
Forms of information that we are familiar with are related to forms we are less familiar with
Evolutionary Bioinformatics aims to make the "new" information-based (rather than gene-based) bioinformatics intelligible both to the "bio" people and the "info" people. Books on bioinformatics have traditionally served gene-hunters, and biologists who wish to construct family trees showing tidy lines of descent. While dealing extensively with the exciting topics of gene discovery and database-searching, such books have hardly considered genomes as information channels through which multiple forms and levels of information have passed through the generations. This "new bioinformatics," contrasts with the "old" gene-based bioinformatics that so preoccupies previous texts.
Evolutionary Bioinformatics extends a line of evolutionary thought that leads from the nineteenth century (Darwin, Butler, Romanes, Bateson), through the twentieth (Goldschmidt, White), and into the twenty first (the final works of the late Stephen Jay Gould). Long an area of controversy, diverging views may now be reconciled. The book is unique in emphasising non-genic aspects of bioinformatics, and linking modern evolutionary biology to a history that extends back to the nineteenth century. Forms of information that we are familiar with (mental, textual) are related to forms we are less familiar with (hereditary).
Prologue.- Part 1: Information and DNA.- Memory - A Phenomenon of Arrangement.- Chargaff’s First Parity Rule.- Information Levels and Barriers.- Part 2: Parity and Non-parity.- Chargaff’s Second Parity Rule.- Stems and Loops.- Chargaff’s Cluster Rule.- Part 3: Variation and Speciation.- Mutation.- Species Survival and Arrival.- The Weak Point.- Chargaff’s GC Rule.- Homostability.- Part 4: Conflict within Genomes.- Conflict Resolution.- Exons and Introns.- Complexity.- Part 5: Conflict between Genomes.- Self/Not-self?.- The Crowded Cytosol.- Part 6: Sex and Error-correction.- Rebooting the Genome.- The Fifth Letter.- Part 7.- Information and Mind.- Memory - What to Arrange and Where?.- Appendix 1.- Appendix 2.- Appendix 3.- Index.