The Comprehensive Sourcebook of Bacterial Protein Toxins 4th Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content.
Evolutionary Aspects of Toxin-Producing BacteriaMobile Genetic Elements and Pathogenicity Islands Encoding Bacterial ToxinsToxin Secretion SystemsDiphtheria ToxinPseudomonas aeruginosa ToxinsBordetella Proteins ToxinsCholera Toxin, Escherichia coli Thermolabile Enterotoxin and Other Vibrio cholerae EnterotoxinsVibrio parahaemolyticus Virulence DeterminantsSalmonella Toxin and Virulence FactorsThe Shiga ToxinsClostridial Neurotoxins: Cellular and Molecular ActionsClostridial Neurotoxins: Uptake and TransportBacillus anthracis ToxinsADP-Ribosylating Toxins Modifying the Actin CytoskeletonLarge Clostridial Cytotoxins Modifying Small GTpases: Structure AspectsLarge Clostridial Cytotoxins Modifying Small GTpases: Cellular AspectsPasteurella multocida ToxinDeamidating ToxinsHelicobaster pylori Vacuolating ToxinBacterial GenotoxinsBasic Mechanism of Pore-Forming ToxinsMembrane-Damaging and Cytotoxic PhospholipasesStructure and Mode of Action of RTX ToxinsPerfringolysin and Related Cholesterol-Dependent CytolysinsStaphylococcus aureus Alpha Toxin and LeucocidinsAerolysinStructural Relationships Between Small ss-Pore-forming Toxins from Clostridium perfringensClostridium perfringens EnterotoxinBacillus cereus EnterotoxinsBacillus Insecticidal ToxinsEscherichia coli Heat-Stable EnterotoxinsSuperantigen ToxinsClostridial Toxins in the Pathogenesis of GangreneEngineering of Botulinum Neurotoxins as Novel Therapeutic ToolsEngineering of Bacterial Toxins for Research and MedicineToxins as Tools in Cell BiologyInhibitors of Toxin EndocytosisInhibitors of Pore-Forming ToxinsBacterial Toxins as Biological Weapons