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The definitive toxicology text for students and early-career professionals-updated and revised to address new research and methods

For more than 45 years, Casarett and Doull's Toxicology has set the standard for providing thorough, academic, and authoritative information in clear and engaging ways. Focusing only on what you need to know and written on a level you can easily understand, it provides a concise yet comprehensive look at the science and clinical field of medical toxicology. This new edition builds on the wide success of previous editions, with extensive updates that make the book more clinically relevant to students and beginners in toxicology, pharmacology, pharmacy, and environmental sciences. Chapter-ending self-assessment Q&As and other features make the learning process more effective and efficient.

Contents:

Preface
UNIT 1 GENERAL PRINCIPLES OF TOXICOLOGY

1. The Evolving Journey of Toxicology: A Historical Glimpse
2. Principles of Toxicology
3. Mechanisms of Toxicity
4. Risk Assessment

UNIT 2 DISPOSITION OF TOXICANTS

5. Absorption, Distribution, and Excretion of Toxicants
6. Biotransformation of Xenobiotics
7. Toxicokinetics

UNIT 3 NON-ORGAN-DIRECTED TOXICITY

8. Chemical Carcinogenesis
9. Genetic Toxicology
10. Developmental Toxicology

UNIT 4 TARGET ORGAN TOXICITY

11. Toxic Responses of the Blood
12. Toxic Responses of the Immune System
13. Toxic Responses of the Liver
14. Toxic Responses of the Kidney
15. Toxic Responses of the Respiratory System
16. Toxic Responses of the Nervous System
17. Toxic Responses of the Cornea, Retina, and Central Visual System
18. Toxic Responses of the Heart and Vascular System
19. Toxic Responses of the Skin
20. Toxic Responses of the Endocrine System
21. Toxic Responses of the Reproductive System

UNIT 5 TOXIC AGENTS

22. Toxic Effects of Pesticides
23. Toxic Effects of Metals
24. Toxic Effects of Solvents and Vapors
25. Toxic Effects of Radiation and Radioactive Materials
26. Toxic Effects of Plants and Animals
27. Food Toxicology: Fundamental and Regulatory Aspects
28. Toxic Effects of Calories
29. Nanoparticle Toxicology

UNIT 6 ENVIRONMENTAL TOXICOLOGY

30. Ecotoxicology
31. Air Pollution

UNIT 7 APPLICATIONS OF TOXICOLOGY

32. Analytical and Forensic Toxicology
33. Clinical Toxicology
34. Occupational Toxicology

Answers to Chapter Questions
Index