Published January, 2011
By Durdica Ugarkovic and Ðurðica Ugarković
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Progress in Molecular and Subcellular Biology
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Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action.

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Published December, 2010
By Robert E. Rhoads and Robert Rhoads
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Progress in Molecular and Subcellular Biology
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This volume presents the response of the eukaryotic translational apparatus to cellular stress and apoptosis, including kinases activated through both the ERK and stress-activated pathways. Both the regulation of initiation and elongation are discussed, and the mechanisms of apoptosis are related to changes in the protein synthesis machinery.

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Published December, 2010
By Alvaro Macieira-Coelho
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Progress in Molecular and Subcellular Biology
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Availability: Available

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Published December, 2010
By Philippe Jeanteur
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Progress in Molecular and Subcellular Biology
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Availability: Available

The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume.

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Published November, 2010
By Philippe Jeanteur
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Progress in Molecular and Subcellular Biology
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Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.

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Published November, 2010
By Alvaro Macieira-Coelho
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Progress in Molecular and Subcellular Biology
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Cell biologists have recently come to understand that asymmetry of division is an important regulatory phenomenon in the fate of a cell. This book describes the phenomenon in different organisms and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.

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Published November, 2010
By Nobuhiro Fusetani, William Kem and William R. Kem
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Progress in Molecular and Subcellular Biology
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In recent years, much biological research has been carried out at molecular and cellular levels, and therefore selective inhibitors of enzymes and selective antagonist/agonists of receptors and channels have become increasingly important research tools.

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Published October, 2010
By Alvaro Macieira-Coelho
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Progress in Molecular and Subcellular Biology
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In this book, tumour growth is perceived as a deviation from the normal development of the human organism. Several mechanisms are proposed to explain the distribution of cancers during the human life span and the decline of the incidence of cancers during human senescence.

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Published October, 2010
By Durdica Ugarkovic and Ðurðica Ugarković
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Progress in Molecular and Subcellular Biology
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Availability: Available

Concerning centromere-specific chromatin modification, it is now evident that all centromeres contain a centromere specific histone H3 variant, CenH3, which replaces histone H3 in centromeric nucleosomes and provides a structural basis that epigenetically defines centromere and differentiates it from the surrounding chromatin.

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Published October, 2010
By Valeria Matranga
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Progress in Molecular and Subcellular Biology
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Availability: Available

Used in ancient oriental medicine as a source of bioactive compounds, sea cucumbers, sea stars and sea urchins are now used for the extraction and purification of cytotoxic, haemolytic, antiviral, antifungal, antifouling, antimicrobial and even anti-tumoural activities.

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