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The history of antibiotics may weIl have begun with the ancient Sudanese-Nubian civilization (see Chapter 1, "Historical Introduction"), but this volume reflects a more contemporary appraisal of the antibiotic era. Pearl River, NY J OSEPH J. 3 CHAPTER 2 Fermentation and Mutational Development of the Tetracyclines J.

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Local anesthetics are among the most widely used drugs. Relief of acute pain, accompanying dental manipulations, for example, and of chronic pain are also accomplished with traditional local anesthetics.

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The problem of cadmium toxicity has become especially important, as cadmium concentrations in the environment have begun to rise owing to a variety of human activities such as mining, the metallurgical industry, coal combustion, and the use of cadmium-containing fertilizers.

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Published November, 2011
By P. Needleman
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Handbook of Experimental Pharmacology
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Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. We now have considerably more insight into the pathways of degradation of organic nitrates and the relationship of the metabolic processes to the biological action of these agents.

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Published November, 2011
By C. Braestrup
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Handbook of Experimental Pharmacology
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Published November, 2011
By L.G. Abood
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Handbook of Experimental Pharmacology
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Published November, 2011
By D.A. Kharkevich and D.M. Aviado
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Handbook of Experimental Pharmacology
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