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Published December, 2011
By E.M. Johnson, D.M. Kochhar and S.T. Chao
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Handbook of Experimental Pharmacology
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Published December, 2011
By G.H. Hitchings and J.F. Acar
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Handbook of Experimental Pharmacology
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Published December, 2011
By Arnold L. Demain and Nadine A. Solomon
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Handbook of Experimental Pharmacology
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(1970) determined an elimination half-life of 14 h in normals as com pared to 60 h in anuric patients. They found a half-life value of 18 h in healthy individuals as compared to 68 h in anuric patients. The findings clearly in dicate that the elimination half-life of strophanthin is prolonged in renal failure.

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The outcome is a further steady development of new antiviral agents which approach the "magic bullets" first proposed by PAUL EHRLICH. Remarkable advances in protein synthetic methods that yield polypeptides which inhibit active sites of viral proteins have aided substantially in the basic and clinical study of these antiviral agents.

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Published December, 2011
By A. S. Milton and C.G. van Arman
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Series: Handbook of Experimental Pharmacology
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In Part l, therefore, we asked our contributors to provide detailed reviews covering the biology of the malaria parasites and their relation with their hosts, the experimental procedures including culture techniques that are necessary to take a drug from primary screening to clinical trial, and an account of antimalarial drug resistance.

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