The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels.
A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine. More importantly, hematopoiesis offers one of the best studied systems with insight into stem cell biology, cellular interaction, development; linage programing and reprograming that are every day influenced by the most mature and understood regulatory networks.
Informs readers how systems medicine may lead to new advances in blood pathophysiology and treatment
Overview of how blood and its diseases have provided an ideal model to study topics of stem cell biology
Topics include intracellular signaling, cellular interactions and diseases of the blood system
Part I: Basic Components.- Systems Hematology: An Introduction.- Quantification and Modeling of Stem Cell - Niche Interaction.- Angiogenesis: A Systems Biology View of Blood Vessel Remodeling.- Erythropoiesis: From Molecular Pathways to System Properties.- Systems Biology of Megakaryocytes.- Systems Biology of Platelet-Vessel Wall Interactions.- Systems Approach to Phagoycte Production and Activation: Neutrophils and Monocytes.- Part II: Physiological Processes.- Stochasticity and Determinism in Models of Hematopoiesis.- Systems Analysis of High–Throughput Data.- Developing a Systems-Based Understanding of Hematopoietic Stem Cell Cycle Control.- A Systems Biology Approach to Iron Metabolism.- Innate Immunity in Disease - Insights from Mathematical Modeling and Analysis.- Modeling Biomolecular Site Dynamics in Immunoreceptor Signaling Systems.- Structure and Function of Platelet Receptors Initiating Blood Clotting.- Part III: Clinical Applications.- Understanding and Treating Cytopenia through Mathematical Modeling.- Drug Resistance.- Etiology and Treatment of Hematological Neoplasms: Stochastic Mathematical Models.- Assessing Hematopoietic (Stem-) Cell Behavior during Regenerative Pressure.- Engineered Cell-Based Therapies: A Vanguard of Design-Driven Medicine.- Part IV: Epilogue.- A Systems Approach to Blood Disorders.- Index.