A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the clinical role of platelets in a wide variety of haematologic, cardiovascular and other disorders, providing a practical, clinically relevant handbook for all clinicians and researchers interested in platelets and their role in disease. Covering platelet physiology, bleeding disorders, thrombotic disorders and antithrombotic therapy. Chapters cover all the conventional and less conventional aspects of platelet involvement in disease, with an emphasis on recent clinical developments. Clear take home messages have been included in each chapter to aid clinical practice. With contributions from leading experts across three continents, Platelets in Hematologic and Cardiovascular Disorders is an up-to-date, well illustrated, practical resource for everyone involved in clinical practice with platelet disorders.
Preface; 1. The structure and production of blood platelets Joseph E. Italiano, Jr; 2. Platelet immunology: structure, functions and polymorphisms of membrane glycoproteins Yasuo Ikeda, Yumiko Matsubara and Tetsuji Kamata; 3. Mechanisms of platelet activation Lawrence Brass and Timothy J. Stalker; 4. Platelet priming Paolo Gresele, Emanuela Dalcinelli and Stafania Momi; 5. Platelets and coagulation José A. López and Ian del Conde; 6. Vessel-wall-derived substances affecting platelets Azad Raiesdana and Joseph Loscalzo; 7. Platelet-Leukocyte-Endothelial cross talk Kevin J. Croce, Masashi Sakuma and Daniel I. Simon; 8. Laboratory investigation of platelets Eduard Shantsila, Timothy Watson and Gregory Y. H. Lip; 9. Clinical approach to the bleeding patient Jos Vermylen and Kathelijne Peerlinck; 10. Thrombocytopenia James Bussel and Andrea Primiani; 11. Reactive and clonal thrombocytosis Ayalew Tefferi; 12. Congenital disorders of platelet function Marco Cattaneo; 13. Acquired disorders of platelet function Michael H. Kroll and Amy A. Hassan; 14. Platelet transfusion therapy Sherrill J. Slichter and Ronald G. Strauss; 15. Clinical approach to the patient with thrombosis Brian G. Choi and Valentin Fuster; 16. Pathophysiology of arterial thrombosis Juan José Badimon, Borja Ibanez and Gemma Vilahur; 17. Platelets and atherosclerosis Stephan Lindemann and Meinrad Gawaz; 18. Platelets in other thrombotic conditions David L. Green, Peter W. Marks and Simon Karpatkin; 19. Platelets in respiratory disorders and inflammatory conditions Paolo Gresele, Stefania Momi, Simon C. Pitchford and Clive P. Page; 20. Platelet pharmacology Dermot Cox; 21. Antiplatelet therapy versus other antithrombotic strategies Nicolai Mejevoi, Catalin Boiangiu and Marc Cohen; 22. Laboratory monitoring of antiplatelet therapy Paul Harrison and David Keeling; 23. Antiplatelet therapy in cardiology Pierluigi Tricoc and Robert A. Harrington; 24. Antiplatelet therapy in cerebrovascular disease James Castle and Gregory W. Albers; 25. Antiplatelet treatment in peripheral arterial disease Raymond Verhaeghe and Peter Verhamme; 26. Antiplatelet treatment of venous thromboembolism Menno V. Huisman, Jaapjan D. Snoep, Jouke T. Tamsma and Marcel M. C. Hovens; Index.