This cutting-edge, interdisciplinary volume describes established and state of the art approaches for exploring the pathways that influence and control appetite, including: behavioural, electrophysiological, neuroanatomical, gene knockout and pharmacological techniques. The book presents key peptide and neurotransmitter systems, together with newly emerging concepts of metabolic signalling and hypothalamic inflammation. The impact of early life experience on neuroendocrine appetite circuits is also looked at, including early programming of these circuits by circulating hormones. Finally, new emerging therapeutic approaches to appetite suppression are discussed, including those linked to bariatric (weight loss) surgery. Neuroendocrinology of Appetite is especially focused on established and emerging technologies and approaches for investigating appetite control. It is written so as to provide an overview of sufficient depth for an undergraduate or new scientist in the field to come up to speed in the complementary approaches used by researchers in this field.
Taking an interdisciplinary approach, the book aims to appeal to all those with a basic, clinical or therapeutic interest in research into obesity and eating disorders.
Foreword vii List of Contributors ix Series Preface xi About the Companion Website xiii 1 Neuroanatomy of Feeding Pathways 1 Brian J. Oldfield, Paul N. Mirabella, and Aneta Stefanidis 2 Afferent Endocrine Control of Eating 24 Wolfgang Langhans and Jens Juul Holst 3 Ontogeny of Neuroendocrine Feeding Circuits 55 Sophie Croizier and Sebastien G. Bouret 4 Hypothalamic Peptides and Meal Patterns 76 Yada Treesukosol and Timothy H. Moran 5 Food Hedonics: Insight from Animal Models 90 Karolina P. Skibicka and Scott E. Kanoski 6 Functional and Anatomical Dissection of Feeding Circuits 112 Deniz Atasoy and Scott M. Sternson 7 Exploring Appetite and Hypothalamic Circuitry through Manipulating Gene Expression 134 Tara Jois and Mark W. Sleeman 8 Electrophysiology of the Appetite Regulating Circuits of the Hypothalamus 151 Nancy Sabatier, John Menzies, and Gareth Leng 9 Functional Neuroimaging of Appetite and Gut Brain Interactions 174 Paul A.M. Smeets and Hubert Preissl 10 Appetite Disorders: From Binge Eating to Anorexia Nervosa 201 Mathieu Mequinion, Susanne la Fleur, and Odile Viltart 11 Future Prospects of the Management of Appetite Disorders Bariatric Surgery 224 Carel le Roux and Karl Neff 12 Discovery of New Drugs for Weight Loss and Prevention of Weight Regain 247 Anders Lehmann, Udo Bauer, Stephan Hjorth, Rudolph L. Leibel and Michael Rosenbaum Index 000