Marine Biomedicine: From Beach to Bedside assesses current efforts in marine biomedicine and evaluates the implications of recent advances on the future of the field. Richly illustrated in full color to enhance reader comprehension, the book covers four sections. The first one addresses the technology that has recently been brought to bear on the study of marine natural products, including omics and bioinformatic techniques. The second focuses on lead discovery and reviews various products and their biomedical potential. Examples of clinically successful marine products and discussions of approaches to the clinic are presented in the third section while the last section discusses prospects for the future of marine biodiscovery. Highlighting new technologies, this valuable resource provides an overview of both what is currently possible in the field as well as a detailed look at what is being done in marine natural products research.
MARINE BIOTECHNOLOGY: INFORMING THE SEARCH Accessing Chemical Diversity through Metagenomics Leah C. Blasiak and Russell T. Hill Chemical Characterization of Marine Organisms Using a Metabolomic Approach Kashif Ali, Robert Verpoorte, Erica G. Wilson, and Young Hae Choi Biosynthetic Approaches to Marine Drug Discovery and Development Eric W. Schmidt Dereplication of Natural Products Using Databases Hartmut Laatsch MARINE BIODISCOVERY: LEAD DISCOVERY Logistic Considerations to Deliver Natural Product Libraries for High-Throughput Screening Ngoc B. Pham, Stephen Toms, David Camp, and Ronald J. Quinn Screening Marine Microbial Libraries Jacqueline L. von Salm, Christopher G. Witowski, Danielle H. Demers, Ryan M. Young, Laurent Calcul, and Bill J. Baker Screening Strategies for Drug Discovery and Target Identification Fatma H. Al-Awadhi, Lilibeth A. Salvador, and Hendrik Luesch Anti-Infective Agents from Marine Sources Cedric Pearce Screening for Antiparasitic Marine Natural Products Ryan M. Young and Eva-Rachele Pesce Central Nervous System Modulators from the Oceans Kh. Tanvir Ahmed, Neil Lax, and Kevin Tidgewell Marine Organisms in Cancer Chemoprevention Eun-Jung Park, Anam Shaikh, Brian T. Murphy, and John M. Pezzuto Off the Beaten Path: Natural Products from Extreme Environments Samantha M. Gromek, Ashley M. West, and Marcy J. Balunas Bioprospecting Fungi and the Labyrinthulomycetes at the Ocean-Land Interface Ka-Lai Pang, Clement K. M. Tsui, E. B. Gareth Jones, and Lilian L. P. Vrijmoed Medicinal Chemistry and Lead Optimization of Marine Natural Products James W. Leahy MARINE PRODUCTS IN BIOMEDICINE The Travails of Clinical Trials with Marine-Sourced Compounds David J. Newman and Gordon M. Cragg Conopeptides, Marine Natural Products from Venoms: Biomedical Applications and Future Research Applications Baldomero M. Olivera, Helena Safavi-Hemami, Martin P. Horvath, and Russell W. Teichert Development and Commercialization of a Fully Synthetic Marine Natural Product Analogue, Halaven (Eribulin Mesylate) Charles E. Chase, Hyeong-wook Choi, Atsushi Endo, Francis G. Fang, and John D. Orr Marine Natural Products in Pharma: How Industry Missed the Boat Guy T. Carter and Valerie S. Bernan In Vitro Model for Defining Neurotoxicity of Anticancer Agents Balanehru Subramanian, Halina Pietraszkiewicz, Joseph E. Media, and Frederick A. Valeriote PROSPECTS FOR THE FUTURE OF MARINE BIODISCOVERY Comments on the Past and Future of Marine Natural Product Drug Discovery William Fenical