about the book…
Standing alone as the first definitive and comprehensive book on the subject, this guide describes the most recent studies on the brain-gut connection and psychosocial issues related to patients experiencing visceral pain. Bringing together leading experts from the top-tiers of the science, this source provides 33 engaging chapters and spans basic concepts in pharmacology, neurobiology, physiology, and psychology to provide a practical approach to the treatment of chronic pain.
Examining a condition that affects up to 25% of the general U.S. population, this source is the only book on the subject to cover both clinical syndromes and neurobiology…ranges from basic mechanisms to diagnosis and clinical treatment of specific syndromes including inflammatory bowel disease, functional abdominal pain, dyspepsia, non-cardiac chest pain, and pelvic pain syndromes…analyzes the latest scientific advances including the role of functional imaging in patient care…integrates fundamental scientific concepts with a practical clinical approach…and supplies 250 figures, and more than 16 color photographs.
about the editors...
PANKAJ JAY PASRICHA is Chief, Division of Gastroenterology and Hepatology; Bassel and Frances Blanton Distinguished Professor of Internal Medicine; and Professor of Neuroscience and Cell Biology and Biomedical Engineering; University of Texas Medical Branch (UTMB), Galveston. Dr. Pasricha also heads the Enteric Neuromuscular Disorders and Pain Center at UTMB and has performed pioneering research in pain and motility disorders. Dr. Pasricha has served on numerous national gastroenterological committees and on panels for the National Institutes of Health. He received the M.D. degree (1982) from the All-India Institute of Medical Sciences, New Delhi, India, and post-graduate training in gastroenterology at the Johns Hopkins University Medical School in Baltimore, Maryland.
WILLIAM D. WILLIS is Director, Cecil H. and Ida M. Green Chair, and Chief of the Division of Comparative Neurobiology, Marine Biomedical Institute; Professor and Chairman, Department of Anatomy & Neurosciences; and Professor, Department of Physiology & Biophysics; University of Texas Medical Branch, Galveston. Dr. Willis has been President of the Society for Neuroscience (1984-1985), the Association of Neuroscience Departments and Programs (1982-1983), and the American Pain Society (1982-1983). He has also been on the Executive Committee of the American Association of Anatomists (1982-1986) and the Council of the International Association for the Study of Pain (1984-1990). He received the M.D. degree (196) from the University of Texas Southwestern Medical School, Dallas, and the Ph.D. degree (1963) from the Australian National University, Canberra.
G. F. GEBHART is Head, Department of Pharmacology, University of Iowa, Iowa City. The author or editor of numerous professional publications, he is editor-in-chief of the Journal of Pain and is the recipient of the Purdue Pharma Prize for Pain Research (2004), as well as the Janssen Award in Gastroenterology for Sustained Achievement (2005). He is a past president of the American Pain Society and President-Elect of the International Association for the Study of Pain. He received the Ph.D. (1971) degree from the University of Iowa, Iowa City.
INTRODUCTION AND OVERVIEW OF VISCERAL AND ABDOMINAL PAIN.
Distinctive Clinical and Biological Characteristics of Visceral Pain. Epidemiology and Socioeconomic Impact of Visceral and Abdominal Pain Syndromes. THE NEUROBIOLOGY AND PSYCHOBIOLOGY OF CHRONIC VISCERAL PAIN. Overview of Pain and Sensitization. Neuroanatomy of Visceral Pain: Pathways and Processes. The Neurobiology of Visceral Nociceptors. The Neurochemical and Molecular Basis of Peripheral Sensitization. Spinal Mechanisms of Visceral Pain and Sensitization. Animal Models of Visceral Pain: Methodology and Validity. Measurement of Pain in Humans. Mechanisms of Visceral Sensitization in Humans. Visceral Pain: Lessons from Functional Brain Imaging. The Neural Basis of Referred Pain. From Sensation to Perception: The Gut-Brain Connection. Visceral Pain, Stress and the Brain-Gut Connection. The Biopsychosocial Approach to Chronic Abdominal Pain. Chronic Pain and Addiction. THERAPY FOR VISCERAL PAIN: SCIENTIFIC BASIS AND PRACTICAL ASPECTS. Molecular Targets: Current and Future. Pharmacology and Practice of Non-Opioid Drugs for Visceral Pain. Pharmacology and Practice of Opioid Drugs for Visceral Pain. Clinical Approach and Management of Visceral Cancer Pain. Neuromodulation Techniques for Visceral Pain from Benign Disorders. Psychological Interventions for Patients with Abdominal Pain. Complementary and Integrative Treatments for Visceral Pain. Clinical Syndromes: Pathophysiology, Diagnosis and Management. Irritable Bowel Syndrome and Functional Abdominal Pain Syndromes. Non-Cardiac Chest Pain. Dyspepsia. Chronic Pancreatitis: Pathophysiology. Abdominal Wall Pain Syndromes. Unexplained Visceral Pain in Children. Functional Biliary Type Pain Syndromes. PELVIC PAIN SYNDROMES. Pelvic Pain Syndromes: Pathophysiology. Pelvic Pain Syndromes: Clinical Features and Management. Interstitial Cystitis and Related Painful Bladder Syndromes: Pathophysiology.