A natural long-chain polymer, chitin is the main component of the cell walls of fungi, the exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and the beaks and internal shells of cephalopods. However, marine crustacean shells are the primary sources of the chitin derivative chitosan. Chitin and chitosan are useful for various biological and biomedical applications, although they have been limited by poor solubility in the past. Current research focuses on increasing their solubility and bioactivity through molecular modifications. The resulting derivatives are receiving much attention for interesting properties, such as biocompatibility, biodegradability, and nontoxicity, that make them suitable for use in the biomedical field. Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments presents current research trends in the synthesis of chitin and chitosan derivatives, their biological activities, and their biomedical applications. Part I discusses basic information about the synthesis and characterization of a variety of derivatives, including the preparation of chitin nanofibers.
Part II covers chitin and chitosan modifications as the basis for biological applications. It describes antioxidant, anti-inflammatory, anticancer, antiviral, anticoagulant, and antimicrobial activities. Part III addresses chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and wound dressing. A must-have reference for novices and experts in biotechnology, natural products, materials science, nutraceuticals, and biomedical engineering, this book presents a wide range of biological and biomedical applications of chitin and chitosan derivatives for drug discovery and development.
Part I Synthesis and Characterization of Chitin and Chitosan Derivatives Chitin and Chitosan Derivatives Se-Kwon Kim and Jayachandran Venkatesan Synthesis, Characterization, and Biomedical Applications of Chitosan and Its Derivatives Hans E. Junginer and Assal M. M. Sadeghi Utilization of Silyl Ethers and Other Protection Groups in the Synthesis of Chitosan Derivatives Vivek S. Gaware, Berglind Eva Benediktsdottir, and Mar Masson Chemical Aspects of Chitin and Chitosan Derivatives Hitoshi Sashiwa Preparation of Chitin and Chitosan Derivatives Having Mercapto Groups Monica Perez, Alberto Gallardo, Juan Alfonso Redondo, and Inmaculada Aranaz Thiolated Chitosan: Preparation, Properties, and Applications Nazma N. Inamdar and Vishnukant Mourya Graft Copolymerization of Acrylic Monomers on Chitosan and Its Derivatives: Recent Developments and Applications M. Prabaharan Preparation of Chitin Nanofibers for Biomedical Application Shinsuke Ifuku, Hiroyuki Saimoto, Kazuo Azuma, Tomohiro Osaki, and Saburo Minami Part II Biological Activities of Chitin and Chitosan Derivatives Anticancer Effects of Chitin and Chitosan Derivatives Mustafa Zafer Karagozlu, Fatih Karadeniz, and Se-Kwon Kim Antidiabetic Applications of Chitosan and Its Derivatives Fatih Karadeniz and Se-Kwon Kim Antioxidant, Antimicroorganism of Chitin, Chitosan, and Their Derivatives Dai-Nghiep Ngo and Se-Kwon Kim Role of Chitosan and Its Derivatives in Cardiovascular Health Dai-Hung Ngo and Se-Kwon Kim Biological Applications of Chitin, Chitosan, Oligosaccharides, and Their Derivatives Panchanathan Manivasagan, Kalimuthu Senthilkumar, Jayachandran Venkatesan, and Se-Kwon Kim Chitin and Chitosan Derivatives for Wound-Healing Applications Willi Paul, R. Deepa, T. V. Anilkumar, and Chandra P. Sharma Part III Biomedical Applications of Chitin and Chitosan Derivatives Chitosan: Amazing Controlled Delivery System Maher Z. Elsabee and Rania E. Morsi Modifications of Chitosan for Gene Delivery Bijay Singh, Sushila Maharjan, Sang-Ki Kang, Yun-Jaie Choi, Myung-Haing Cho, and Chong-Su Cho Prospective Corollary of Ophthalmic Nanomedicine: A Concept Shift toward Chitosan-Based Mucoadhesive Nanomedicine Farhan Jalees Ahmad, Sohail Akhter, Mohammad Zaki Ahmad, Farshad Ramazani, Mohammad Samim, Musarrat Husain Warsi, Mohammad Anwar, and Ziyaur Rahman Biomedical Applications of Chitin and Chitosan Derivatives Sougata Jana, Arijit Gandhi, Kalyan Kumar Sen, and Sanat Kumar Basu Chitosan Derivatives for Oral Delivery of Insulin Anumita Chaudhury and Surajit Das Chitosan and Chitosan Derivatives for Mucosal Delivery of Biopharmaceutical Drugs Fernanda Andrade, Francisca Araujo, and Bruno Sarmento Chitosans as Delivery Vectors in Biomedical Applications Vandana Patravale and Swati Vyas Chitosan as Coating Material for Titanium Implants Ramona Lieder and Olafur E. Sigurjonsson Current Scenario and Future Prospects of Chitosan in Dentistry Manal Farea, Ahmad Sukari Halim, and Nor Shamsuria Omar Bionanocomposites of Chitosan for Multitissue Engineering Applications P. N. Sudha, S. Aisverya, Maximas H. Rose, Jayachandran Venkatesan, and Se-Kwon Kim Recent Advancements in Research on Chitin and Chitosan Derivatives for Drug Delivery Application P. N. Sudha, T. Gomathi, K. Nasreen, Jayachandran Venkatesan, and Se-Kwon Kim Chitosan and Chitosan Derivatives as Potential Adjuvants for Influenza Vaccine Nguyen Anh Dzung