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Cardiovascular Toxicology, Fourth Edition
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Main description:

Focused extensively on the toxic effect of chemicals on the cardiovascular system, Cardiovascular Toxicology, Fourth Edition is comprised of several key sections beyond cardio and vascular toxicity, such as principles of myocardial cell injury and key methods of assessing cardiovascular function.

New developments include:

  • expanded chapter on passive smoking, which includes adverse effects of smoking, and the effects of secondary smoke

  • new chapter on the negative effects from environmental chemicals on the cardiovascular system

  • chapters covering antibacterial agents and endotoxins include new information on cardiovascular toxicity of antimicrobials, as well as anti-viral agents, antibacterial agents, and other agents


Part I – Introduction.

Chapter 1: Advances in Cardiovascular Toxicology, Y. James Kang, Ph.D., DVM

Chapter 2: Pathobiology of Myocardial Ischemic Injury, L. Maximilian Buja, M.D.

Part II – Methods

Chapter 3: Nonclinical Safety Assessment of the Cardiovascular Toxicity of Drugs and Combination Medical Devices, Shayne C. Gad, Ph.D.

Chapter 4: Novel Approaches in the Evaluation of Cardiovascular Toxicity, Enrique Chacon, Ph.D., John J. Lemasters, M.D., Ph.D., Colleen Doherty, Ph.D., Joseph W. Starnes, Ph.D., and Vivek Kadambi, Ph.D.

Chapter 5: Cardiovascular Dynamics in Conscious Primates, Stephen F. Vatner, Ph.D., You-Tang Shen, M.D., and Franco Rossi, MSEE

Part III – Cardiotoxicity

Chapter 6: Cardiovascular Toxicity of Antimicrobials, Daniel P. Healy, Pharm.D.

Chapter 7: Cardiotoxicity of Anthracyclines and Other Antineoplastic Agents, Jane M. Pruemer, Pharm.D.

Chapter 8: Catecholamine-induced Cardiomyopathy, Naranjan S. Dhalla, Ph.D., M.D. and Melissa R. Dent, Ph.D.

Chapter 9: Adverse Effects of Centrally Acting Drugs on the Cardiovascular System, Mitchell S. Finkel, M.D., William F. Pettit, M.D. and Don Mishra, M.D.

Chapter 10: Adverse Effects of Drugs on Electrophysiological Properties of the Heart, Cynthia Carnes, Ph.D., Gary A. Gintant, and Robert L. Hamlin, DVM, Ph.D.

Chapter 11: Cardiovascular Effects of Steroidal Agents, Russell B. Melchert, Ph.D., Richard H. Kennedy, Ph.D., and Scott M. Belcher, Ph.D.

Chapter 12: Cardiotoxicity of Industrial Chemicals and Environmental Pollutants, Nachman Brautbar, M.D., John A. Williams, II, M.P.H., and Michael P. Wu, M.P.H.

Chapter 13: Adverse Effects of Cigarette Smoking on the Cardiovascular System, Stanton A. Glantz, Ph.D.

Part IV – Vascular Toxicity

Chapter 14: Overview of Vascular Toxicology, Kenneth S. Ramos, Ph.D. and E. Spencer Williams, Ph.D.

Chapter 15: Pathobiology of the Vascular Response to Injury, Peter G. Anderson, DVM, Ph.D.

Chapter 16: The Arterial Media as a Target of Injury by Chemicals, Paul J. Boor, M.D. and Daniel. J. Conklin, Ph.D.


ISBN-13: 9781420044744
Publisher: Taylor & Francis (CRC Press)
Publication date: September, 2008
Pages: 684