Main description:

Controversies in Vaccine Safety: A Critical Review covers the topic of the safety of vaccines, an area that is often assumed rather than demonstrated. Further, indications that any vaccine may have adverse effects tend to be downplayed in context to presumed vaccine effectiveness against infectious disease.

In reality, some vaccines have much better safety profiles than others and the cumulative safety impact of multiple vaccinations may be different than a simple combination of individual vaccines. The latter point becomes more significant as western medicine adds more vaccines to the recommended schedule each year.

Most of the existing mainstream literature tends to be both narrowly focused and dismissive of concerns about adverse effects. The latter is particularly problematic in cases where effectiveness has not been well established.

Contents:

1. Vaccine safety concerns: separating fact from fiction 2. Vaccine effectiveness: several views from the historical record 3. Vaccines as tools against infectious diseases in veterinary medicine 4. Vaccines and Autoimmunity 5. Dietary, infectious and vaccine antigens and toxic metals as contributors of autoimmunity 6. Vaccine components and host interactions: genetics, epigenetics, antigenic load and compromised immunity 7. Low dose thimerosal (ethyl-mercury) neurotoxicity and vaccines 8. Vaccine Induced Allergies 9. Immunotoxicology of vaccine adjuvants 10. Aluminum adjuvants 11. Aluminium adjuvant alternatives: a chemist's point of view 12. Characterization and pathophysiology of macrophagic myofasciitis syndrome 13. Neurodevelopmental toxicity associated with the use of aluminum vaccine adjuvants 14. Immunotoxicity of nanoparticles: implication in vaccine adjuvant use 15. Alternatives to current adjuvants 16. The significance of heterologous immunity in shaping immune responses to vaccinations and infections: a double edged sword 17. Controversies in Vaccines safety, Adjuvants and ASIA syndrome 18. Vaccine safety in veterinary practice 19. Over-immunization in sheep and associated neurodegenerative syndromes 20. Adverse reactions associated with HPV vaccines: examination of epidemiological studies and pharmacovigilance data 21. HPV vaccine and orthostatic hypotension 22. Research on drugs and vaccines: a call for formal study of drug harm 23. Seeking the correct balance between vaccine social benefits versus individual adverse effects 24. New classification of vaccine adverse events causality criteria by the WHO 25. HPV vaccine and ovarian failure: deficiencies in the clinical trial study design and vaccine surveillance systems reporting guidelines which impede accurate assessment of vaccine-related risks 26. Reanalysis of the U.S CDC data on the timing of the first MMR vaccine and autism incidence 27. The role of institutional scientific misconduct