Main description:

Multiple sclerosis is one of the major current problems in neurol ogical practice. It remains incompletely understood, yet is a common cause of chronic disability in developed Western so cieties: Patients with the disease have difficulty understanding what has happened to them and become bewildered by the con trast between the evidently large body of knowledge concerning the clinical manifestations and course of the disease, and the conflicting views they so often receive from different specialists as to the best current management of their disease. As in so many disorders for which treatment is only partially effective, at best, "alternative" therapies abound. Dr. Rudick and Dr. Goodkin have extensive experience in the day-to-day management of multiple sclerosis at the Mellen Center for Multiple Sclerosis Treatment and Research, attached to the Cleveland Clinic. In this book they have assembled a group of experts from several countries and have provided a comprehensive review of the results of different treatments of the disease. Each treatment is considered in the light of its proposed scientific basis or mode of action, and in relation to ethical and trial design issues. This information deserves to be made widely available. As the treatment of multiple sclerosis enters a new era as a result of the new understanding of the cellular mechanisms of demyelination and the molecular biology of the immune response, this information about current treatments assumes additional importance. The book is of interest to all physicians concerned with the management of patients with the disease.

Contents:

1 Experimental Therapies for Multiple Sclerosis: Historical Perspective.- 2 The Natural History of Multiple Sclerosis.- 3 Assessing the Outcome of Experimental Therapies in Multiple Sclerosis Patients.- 4 Design and Statistical Issues Related to Testing Experimental Therapy in Multiple Sclerosis.- 5 Pathogenesis of Multiple Sclerosis: Relationship to Therapeutic Strategies.- 6 Treatment of Multiple Sclerosis with ACTH and Corticosteroids.- 7 Treatment of Multiple Sclerosis with Azathioprine.- 8 Treatment of Multiple Sclerosis with Copolymer I.- 9 Treatment of Multiple Sclerosis with Cyclophosphamide.- 10 Treatment of Multiple Sclerosis with Cyclosporine A.- 11 Treatment of Multiple Sclerosis with Interferons.- 12 Treatment of Multiple Sclerosis with Plasma Exchange.- 13 Total Lymphoid Irradiation in Multiple Sclerosis.- 14 Specific Immunotherapeutic Strategies: Lessons from Myelin Basic Protein-Induced Experimental Allergic Encephalomyelitis.- 15 Experimental Approaches to Specific Immunotherapy in Multiple Sclerosis.