Main description:

This volume of The Year in Immunology series features reviews of topics in human immunology, including B1 B cells, BCL-2 family members, Wiskott-Aldrich syndrome, reverse vaccinology, anti-b2-glycoprotein I, the role of autoimmunity In thromboangiitis obliterans (Buerger's Disease), long pentraxin PTX3 as a paradigm for humoral pattern recognition molecules, and control of inflammatory heart disease by CD4+ T cells.

Contents:

The proper study: preface to The Year in Immunology v Noel R. Rose The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules 1 Alberto Mantovani, Sonia Valentino, Stefania Gentile, Antonio Inforzato, Barbara Bottazzi, and Cecilia Garlanda The role of autoimmunity in thromboangiitis obliterans (Buerger s disease) 15 Siva S. Ketha and Leslie T. Cooper Wiskott-Aldrich syndrome: a comprehensive review 26 Michel J. Massaad, Narayanaswamy Ramesh, and Raif S. Geha Anti- -glcoprotein I antibodies 44 Rohan Willis and Silvia S. Pierangeli Getting away with murder: how does the BCL-2 family of proteins kill with immunity? 59 Thibaud T. Ranault and Jerry E. Chipuk Control of inflammatory heart disease by CD4+ T cells 80 Jobert G. Barin and Daniela ihakova Human B-1 cells take the stage 97 Thomas L. Rothstein, Daniel O. Griffin, Nichol E. Holodick, Tam D. Quach, and Hiroaki Kaku Reverse vaccinology in the 21st century: improvements over the original design 115 Claudio Donati and Rino Rappuoli The National Institutes of Health Center for Human Immunology, Autoimmunity, and Inflammation: history and progress 133 Howard B. Dickler, J. Philip McCoy, Robert Nussenblatt, Shira Perl, Pamela A. Schwartzberg, John S. Tsang, Ena Wang, and Neil S. Young