Main description:

This book focuses on the role of the endocannabinoid system in local and systemic inflammation, with individual chapters written by experts in the field of cannabinoid research and medicine. The topics explore the actions of the endocannabinoid system on the immune system, including neuroinflammation in autoimmune disorders such as multiple sclerosis, and in neurodegenerative disorders such as Huntington's and Alzheimer's, as well as local and systemic inflammatory conditions affecting organs including the eye (uveitis and corneal inflammation), the bladder (interstitial cystitis), pancreas (diabetes), cardiovascular system (stroke), joints (arthritis), and sepsis. The objective of this book is to provide knowledge transfer on the use of cannabinoids in inflammatory disease by critically examining preclinical and clinical research on the immunomodulatory actions of the endocannabinoid system, with specific emphasis on the actions of cannabinoids in diseases where inflammation is a prominent component. By drawing these results together, we seek to provide further understanding of the complexities of endocannabinoid system modulation of immune function and identify potential uses and limitations for cannabinoid-based therapeutics.

Contents:

Preface
Inflammation and the Endocannabinoid System
Cannabinoids in Multiple Sclerosis
Huntington's Disease and the Endocannabinoid System
Alzheimer's, Neuroinflammation and the Endocannabinoid System
The Endocannabinoid System's Role in Ocular Inflammation
Cannabidiol as a Potential Clinical Therapeutic Agent for the Reduction of Pancreatic Inflammation in Early Type 1 Diabetes Mellitus
Role of the Endocannabinoid System in Interstitial Cystitis
Arthritis and the Endocannabinoid System
Cannabinoid 2 Receptor Activation in Sepsis
Immune Modulation by Cannabinoids During Central Nervous System Injury-induced Neuroinflammation
Lead Author Biographies
Contributing Author Biographies
References