Next-Generation Sequencing has enabled faster and cheaper mapping of DNA/RNA. It allows genomic comparisons and accelerates genomic discoveries. This book will focus on the struggle of innovation, technological advancement, and business realities that has created the current patchwork of commercial genomic analysis tools. It will map the progress and accuracy of mapping genomes from the SNP based microarray to NGS and on to the single molecule sequencing technologies being developed today.
Early Technological Advances that Enabled NGS and Genomic Assay Technologies. The Challenges of Sequencing for Commercial Applications. The Role of Commercial Pressures and Research Interests in Advancing Commercial Sequencing. Technological Advances that Enabled NGS. Bioinformatic Problems in the Analysis of NGS Data. Identifying Structural Variation Through Sequencing. Challenges with Sequencing non-human Genomes. The Political and Social Effects from NGS and SNP Assays. Problem Solving and Organizational Methods for Rapid Development. The Role of Software in the Commercialization of Sequencing. Visualization's Role in Understanding Genomic Data. The Diagnostic Application of Sequencing in Detecting Disease. Sequencing Technologies that were not Commercial Successes. Solving the Restrictions of NGS and the Next Sequencing Technologies. Lessons from the Development of Sequencing Development on other Fields.