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Textbook of Drug Design and Discovery
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Main description:

Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects. Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery. The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding).
The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.


Contents:

Introduction to Drug Design and Discovery Ulf Madsen and Povl Krogsgaard-Larsen Molecular Recognition Thomas Balle and Tommy Liljefors Ligand-Based Drug Design Erica S. Burnell, David E. Jane, and Robert J. Thatcher Biostructure-Based Drug Design Flemming Steen Jorgensen and Jette Sandholm Kastrup Drug-Like Properties and Decision Making in Medicinal Chemistry Jan Kehler, Lars Kyhn Rasmussen, and Morten Jorgensen Chemical Biology Louise Albertsen and Kristian Stromgaard Natural Products in Drug Discovery Guy T. Carter In Vivo Imaging in Drug Discovery Jesper L. Kristensen and Matthias M. Herth Peptide and Protein Drug Design Jesper Lau and Soren Ostergaard Prodrugs in Drug Design and Development Jarkko Rautio and Krista Laine Enzyme Inhibitors: Biostructure- and Mechanism-Based Design Robert A. Copeland and P. Ann Boriack-Sjodin Receptors: Structure, Function, and Pharmacology Hans Brauner-Osborne Ion Channels: Structure and Function Soren-Peter Olesen, Bo Hjorth Bentzen, and Daniel B. Timmermann Neurotransmitter Transporters: Structure, Function, and Drug Binding Claus J. Loland and Ulrik Gether GABA and Glutamic Acid Receptor and Transporter Ligands Bente Frolund and Lennart Bunch Acetylcholine Anders A. Jensen Histamine Receptors Iwan de Esch, Henk Timmerman, and Rob Leurs Dopamine and Serotonin Benny Bang-Andersen, Lena Tagmose, and Klaus P. Bogeso Opioid and Cannabinoid Receptors Rasmus P. Clausen and Harald S. Hansen Neglected Diseases Soren B. Christensen and Ib C. Bygbjerg Anticancer Agents Fredrik Bjorkling, Jose Moreira, and Jan Stenvang Targeting Receptor Tyrosine Kinases Bo Falck Hansen and Steen Gammeltoft Antibiotics Smitha Rao C.V., Piet Herdewijn, and Anastassios Economou


PRODUCT DETAILS

ISBN-13: 9781498702782
Publisher: Productivity Press
Publication date: July, 2016
Pages: 440
Weight: 1133g
Availability: Contact supplier
Subcategories: Pharmacology
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