Main description:

The molecular biological revolution and the mapping of the human genome continue to provide new challenges and opportunities for drug research and design. Future medicinal chemists and drug designers must have a firm background in a number of related scientific disciplines in order to understand the conversion of new insight into lead structures and subsequently into drug candidates. Classroom tested and student approved, Textbook of Drug Design and Discovery, Fourth Edition describes the manner in which medicinal chemists utilize the various fields upon which they draw and the specific strategies they employ to advance promising molecules into clinical use for the treatment of disease.

This text integrates a number of related scientific disciplines, including advanced synthetic chemistry, computational chemistry, biochemistry, structural biology, and molecular pharmacology, to provide current and comprehensive information on all aspects of drug design and discovery.

Extensively revised, new topics in the fourth edition include:

• Biostructure-based and ligand-based drug design


• Chemical biology


• Natural products


• Imaging


• Neurotransmitter transporters


• Opioid and cannabinoid receptors


• Hypnotics


• Neglected diseases


• Immunomodulating agents


• Antibiotics

The first part of the book covers general aspects, methods, and principles for drug design and discovery, and the second part covers specific targets and diseases. The text contains more than 300 color figures and 24 tables for rapid assimilation. Each chapter includes references for further study. Most chapters also provide the background and history needed to provide a context for students, as well as conclusions that summarize the points most relevant to emerging areas of research in drug design.

Contents:

Introduction to Drug Design and Discovery, P. Krogsgaard-Larsen and L. Bunch

Molecular Recognition in Ligand–Protein Binding, T. Liljefors

Biostructure-Based Drug Design, F. S. Jørgensen and J. S. Kastrup

Ligand-Based Drug Design, I. Pettersson, T. Balle, and T. Liljefors

Chemical Biology, K. Strømgaard

Stereochemistry in Drug Design, M. B. Mayo-Martin and D. E. Jane

Natural Products in Drug Discovery, G. T. Carter

Imaging in Drug Discovery and Development, M. Rudin and T. Mueggler

Peptides and Peptidomimetics, M. Cai, V. V. Kulkarni, and V. J. Hruby

Prodrugs: Design and Development, A. Buur and N. Mørk

Metals in Medicine: Inorganic Medicinal Chemistry, H. R. Hansen and O. Farver

Enzyme Inhibitors: Biostructure-Based and Mechanism-Based Designs, R. A. Copeland, R. R. Gontarek, and L. Luo

Receptors: Structure, Function, and Pharmacology, H. Bräuner-Osborne

Ion Channels: Structure and Function, S.-P. Olesen and D. B. Timmermann

Neurotransmitter Transporters: Structure and Function, C. J. Loland and U. Gether

GABA and Glutamic Acid Receptor Ligands, B. Frølund and U. Madsen

Acetylcholine, A. A. Jensen and P. Krogsgaard-Larsen

Histamine Receptors, I. de Esch, H. Timmerman, and R. Leurs

Dopamine and Serotonin, B. Bang-Andersen and K. P. Bøgesø

Opioid and Cannabinoid Receptors, R. P. Clausen and H. S. Hansen

Hypnotics, B. Ebert and K. A. Wafford

Neglected Diseases, S. B. Christensen

Immunomodulating Agents, U. G. Sidelmann

Anticancer Agents, F. Björkling and L. H. Jensen

Antiviral Drugs, E. De Clercq

Antibiotics, P. Herdewijn

Index