Sjogren's Syndrome: Novel Insights in Pathogenic, Clinical and Therapeutic Aspects provides the reader with an overview of current knowledge about Sjogren's Syndrome. The book summarizes the huge amount of literature concerning related advances in genetic background, pathogenesis, clinical picture, and therapeutic approaches. It integrates basic immunology concepts, clinical aspects, and pharmacological issues. Scientific progress has allowed us to unmask novel pathogenic mechanisms, to perform genome wide studies, and to identify clinical and serological features associated with different disease subsets and, eventually, different disease prognoses. In addition, the increasing knowledge about SS pathogenesis provides the rationale to employ targeted therapies in SS as has already occurred in rheumatoid arthritis and systemic lupus erythematosus.
-Genetics and epigenetics in SS-Environmental factors in SS development-SS classification criteria in 2014: shall we improve them?-Glandular epithelium: innocent bystander or leading actor?-T cells in SS pathogenesis: more than just Th1 and Th2-B cells in SS pathogenesis: the good and the evil-Other immune cells in SS pathogenesis-Autoantibodies in SS: SSA, SSB and beyond-The kaleidoscope of clinical picture in SS -Extra-glandular manifestations in SS-Outcome measures in SS-SS associated lymphoma-Novel therapeutic strategies in SS: B-cell targeting-Novel therapeutic strategies in SS: T-cell targeting