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Main description:

Pulmonary embolism (PE) is the third most common acute cardiovascular disease after acute myocardial infarction and stroke. This fully updated third edition supplies the latest information on epidemiology, methods of diagnosis, preferred diagnostic pathways, new medications including the new anticoagulants, and new recommendations for prophylaxis and treatment of pulmonary embolism and its immediate cause, deep vein thrombosis.



  • An essential and comprehensive resource for physicians and allied professionals in the field of this difficult–to–diagnose and life threatening condition

  • Highly illustrated with numerous tables and graphs alongside clear concise text

  • Includes chapters addressing pulmonary embolism (PE) and deep venous thrombosis (DVT) in relation to diseases and disorders such as; chronic heart failure, cancer, diabetes, stroke, chronic obstructive pulmonary disease (COPD) and many more

  • Discusses the role the different tools in imaging for PE, including, echocardiography, multidetector computed tomography (CT), single photon emission computed tomography (SPECT), ventilation–perfusion (V–Q) imaging, dual energy CT, and magnetic resonance angiography

  • Contains 29 new chapters and includes new content on epidemiology of deep venous thrombosis; use of the new anticoagulants (dabigatran, rivaroxaban, and apixaban) for DVT and PE; indications and results with thrombolytic therapy and with vena cava filters; and information and indications for invasive mechanical thrombectomy

  • Written by an internationally recognized and respected expert in the field


This book is a dependable and well referenced resource for in–depth information about pulmonary embolism (PE) and deep venous thrombosis (DVT).


Praise for previous editions


"I would recommend this book to all physicians looking after patients with venous thromboembolism .The single author style has the advantage of a consistent format and lack of repetition, and the book is very well written." (Cardiology News, December 2008)


Paul Stein has used his vast knowledge and perspective to organize [t]his definitive text .In this long–awaited second edition he builds on the knowledge base regarding this common and yet often misdiagnosed condition. This text fills a gap in the knowledge–base of the physician, nurse, or therapist who cares for patients with pulmonary embolism. By using a clear and organized format with many graphs and diagrams, Stein provides detailed information beyond the scope of an online review, but in a readily searchable and easily accessible format. Stein does a nice job of explaining the challenges of using intermediate end points in the assessment of efficacy. Stein is clearly one of the world s experts, and this far–reaching volume is a pleasure to read. (Respiratory Care, September 2008)


This textbook is cohesive, tightly organized, and has no repetition It is beautifully illustrated [and] is my go to source for rapid reference. (Journal of Interventional Cardiology)


"An excellent contribution to the relevant contemporary literature I enjoyed reading the book and recommend it to my colleagues." (World Journal of Surgery)


Back cover:

Pulmonary embolism (PE) is the third most common acute cardiovascular disease after acute myocardial infarction and stroke. This fully updated third edition supplies the latest information on epidemiology, methods of diagnosis, preferred diagnostic pathways, new medications including the new anticoagulants, and new recommendations for prophylaxis and treatment of pulmonary embolism and its immediate cause, deep vein thrombosis.



  • An essential and comprehensive resource for physicians and allied professionals in the field of this difficult–to–diagnose and life threatening condition

  • Highly illustrated with numerous tables and graphs alongside clear concise text

  • Includes chapters addressing pulmonary embolism (PE) and deep venous thrombosis (DVT) in relation to diseases and disorders such as; chronic heart failure, cancer, diabetes, stroke, chronic obstructive pulmonary disease (COPD) and many more

  • Discusses the role the different tools in imaging for PE, including, echocardiography, multidetector computed tomography (CT), single photon emission computed tomography (SPECT), ventilation–perfusion (V–Q) imaging, dual energy CT, and magnetic resonance angiography

  • Contains 29 new chapters and includes new content on epidemiology of deep venous thrombosis; use of the new anticoagulants (dabigatran, rivaroxaban, and apixaban) for DVT and PE; indications and results with thrombolytic therapy and with vena cava filters; and information and indications for invasive mechanical thrombectomy

  • Written by an internationally recognized and respected expert in the field


This book is a dependable and well referenced resource for in–depth information about pulmonary embolism (PE) and deep venous thrombosis (DVT).


Praise for previous editions


"I would recommend this book to all physicians looking after patients with venous thromboembolism .The single author style has the advantage of a consistent format and lack of repetition, and the book is very well written." (Cardiology News, December 2008)


Paul Stein has used his vast knowledge and perspective to organize [t]his definitive text .In this long–awaited second edition he builds on the knowledge base regarding this common and yet often misdiagnosed condition. This text fills a gap in the knowledge–base of the physician, nurse, or therapist who cares for patients with pulmonary embolism. By using a clear and organized format with many graphs and diagrams, Stein provides detailed information beyond the scope of an online review, but in a readily searchable and easily accessible format. Stein does a nice job of explaining the challenges of using intermediate end points in the assessment of efficacy. Stein is clearly one of the world s experts, and this far–reaching volume is a pleasure to read. (Respiratory Care, September 2008)


This textbook is cohesive, tightly organized, and has no repetition It is beautifully illustrated [and] is my go to source for rapid reference. (Journal of Interventional Cardiology)


"An excellent contribution to the relevant contemporary literature I enjoyed reading the book and recommend it to my colleagues." (World Journal of Surgery)


Contents:

Prologue xi


Preface to the Third Edition xiii


Introduction 1


Part I Prevalence, risks, and prognosis of pulmonary embolism and deep venous thrombosis


1 Pulmonary embolism and deep venous thrombosis at autopsy 5


2 Incidence of pulmonary embolism and deep venous thrombosis in hospitalized patients and in emergency departments 18


3 Case fatality rate and population mortality rate from pulmonary embolism and deep venous thrombosis 24


4 Prognosis inacutepulmonary embolism based on right ventricular enlargement and biochemical markers in stable patients 31


5 Prognosis inacutepulmonary embolism based on scoring systems 43


6 Pulmonaryembolismfollowingdeep venous thrombosis and outcome with untreated pulmonary embolism 49


7 Resolutionofpulmonaryembolism 54


8 Upper extremity deep venous thrombosis 61


9 Thromboembolic disease involving the superior vena cava and brachiocephalic veins 66


10 Venous thromboembolic disease in the four seasons 69


11 Regional differences in the United States of rates of diagnosis of pulmonary embolism and deep venous thrombosis and mortality from pulmonary embolism 73


12 Venous thromboembolism according to age and in the elderly 78


13 Pulmonary thromboembolism in infants and children 95


14 Venous thromboembolism in men and women 99


15 Pulmonary embolism and deep venous thrombosis in blacks and whites 103


16 Pulmonary thromboembolism in Asians/Pacific Islanders 108


17 Pulmonary thromboembolism in American Indians and Alaskan Natives 116


18 Venous thromboembolism in patients with cancer 118


19 Venous thromboembolism in patients with heart failure 128


20 Obesity as a risk factor in venous thromboembolism 133


21 Hypertension, smoking, and cholesterol 139


22 Overlap of venous and arterial thrombosis risk factors 141


23 Venous thromboembolism in patients with ischemic and hemorrhagic stroke 143


24 Paradoxical embolism 146


25 Pulmonary embolism and deep venous thrombosis in hospitalized adults with chronic obstructive pulmonary disease 149


26 Pulmonary embolism and deep venous thrombosis in hospitalized patients with asthma 156


27 Deep venous thrombosis and pulmonary embolism in hospitalized patients with sickle cell disease 158


28 Diabetesmellitus and risk of venous thromboembolism 162


29 Risk of venous thromboembolism with rheumatoid arthritis 164


30 Venous thromboembolism with inflammatory bowel disease 166


31 Venous thromboembolism with chronic liver disease 168


32 Nephrotic syndrome 171


33 Human immunodeficiency virus infection 173


34 Venous thromboembolism in pregnancy 176


35 Amniotic fluid embolism 182


36 Air travel as a risk for pulmonary embolism and deep venous thrombosis 184


37 Estrogen–containing oral contraceptives and venous thromboembolism 187


38 Estrogen and testosterone in men 192


39 Tamoxifen 194


40 Venous thromboembolism following bariatric surgery 198


41 Hypercoagulable syndrome 204


Part II Diagnosis of deep venous thrombosis


42 Deep venous thrombosis of the lower extremities: clinical evaluation 215


43 Clinical scoring system for assessment of deep venous thrombosis 220


44 Clinical probability score plus single negative ultrasound for exclusion of deep venous thrombosis 223


45 D–dimer for the exclusion of acute deep venous thrombosis 225


46 D–dimer combined with clinical probability assessment for exclusion of acute deep venous thrombosis 234


47 D–dimer and single negative compression ultrasound for exclusion of deep venous thrombosis 236


48 Contrast venography 237


49 Compression ultrasound for the diagnosis of deep venous thrombosis 240


50 Impedance plethysmography and fibrinogen uptake tests for diagnosis of deep venous thrombosis 247


51 Ascending CT venography and venous phase CT venography for diagnosis of deep venous thrombosis 250


52 Magnetic resonance venography for diagnosis of deep venous thrombosis 255


53 P–selectin and microparticles to predict deep venous thrombosis 260


Part III Diagnosis of acute pulmonary embolism


54 Clinical characteristics of patients with no prior cardiopulmonary disease 265


55 Relation of right–sided pressures to clinical characteristics of patients with no prior cardiopulmonary disease 272


56 The history and physical examination in all patients irrespective of prior cardiopulmonary disease 275


57 Clinical characteristics of patients with acute pulmonary embolism stratified according to their presenting syndromes 280


58 Clinical assessment in the critically ill 286


59 The electrocardiogram 289


60 The plain chest radiograph 303


61 Arterial blood gases and the alveolar arterial oxygen difference in acute pulmonary embolism 308


62 Fever in acute pulmonary embolism 316


63 Leukocytosis in acute pulmonary embolism 319


64 Alveolar dead–space in the diagnosis of pulmonary embolism 321


65 Empirical assessment and clinical models for diagnosis of acute pulmonary embolism 324


66 Prognostic models for pulmonary embolism 329


67 D–dimer for the exclusion of acute pulmonary embolism 335


68 D–dimer combined with clinical probability for exclusion of acute pulmonary embolism 346


69 D–dimer in combination with amino–terminal pro–B–type natriuretic peptide for exclusion of acute pulmonary embolism 349


70 Tissue plasminogen activator, plasminogen activator inhibitor–1, and thrombin antithrombin III complexes in the exclusion of acute pulmonary embolism 350


71 Echocardiogram in the diagnosis of acute pulmonary embolism 352


72 Trends in the use of diagnostic imaging in patients hospitalized with acute pulmonary embolism 356


73 Techniques of perfusion and ventilation imaging 358


74 Ventilation perfusion lung scan criteria for interpretation prior to the Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED) 363


75 Observations from PIOPED: ventilation perfusion lung scans alone and in combination with clinical assessment 367


76 Ventilation perfusion lung scans according to complexity of lung disease 374


77 Perfusion lung scans alone in acute pulmonary embolism 376


78 Probability interpretation of ventilation perfusion lung scans in relation to the largest pulmonary arterial branches in which pulmonary embolism is observed 379


79 Revised criteria for evaluation of lung scans recommended by nuclear physicians in PIOPED 381


80 Criteria for very–low–probability interpretation of ventilation perfusion lung scans, 385


81 Probability assessment based on the number of mismatched segmental equivalent perfusion defects 391


82 Probability assessment based on the number of mismatched vascular defects and stratification according to prior cardiopulmonary disease 395


83 The addition of clinical assessment to stratification according to prior cardiopulmonary disease further optimizes the interpretation of ventilation perfusion lung scans 401


84 Pulmonary scintigraphy scans since PIOPED 407


85 Single photon emission computed tomographic (SPECT) lung scans 412


86 SPECT with radiolabeled markers 426


87 Standard and augmented techniques in pulmonary angiography 427


88 Subsegmental pulmonary embolism 435


89 Quantification of pulmonary embolism by conventional and CT angiography 440


90 Complications of pulmonary angiography 442


91 Contrast–enhanced spiral CT for the diagnosis of acute pulmonary embolism before the Prospective Investigation of Pulmonary Embolism Diagnosis 446


92 Methods of PIOPED II 458


93 Multidetector spiral CT of the chest for acute pulmonary embolism: results of the PIOPED II trial 467


94 Multidetector CT pulmonary angiography since PIOPED II 473


95 Outcome studies of pulmonary embolism versus accuracy 478


96 Contrast–induced nephropathy 480


97 Radiation exposure and risk 483


98 Magnetic resonance angiography for the diagnosis of acute pulmonary embolism 490


99 Serial noninvasive leg tests in patients with suspected pulmonary embolism 499


100 Diagnosis of pulmonary embolism in the coronary care unit 501


101 Silent pulmonary embolism with deep venous thrombosis 506


102 Fat embolism syndrome 511


103 Diagnostic approach to acute pulmonary embolism 516


Part IV Prevention and treatment of deep venous thrombosis and pulmonary embolism


104 Warfarin and other vitamin K antagonists 523


105 Unfractionated heparin, low–molecular–weight heparin,heparinoid, and pentasaccharide 531


106 Parenteral inhibitors of factors Va, VIIIa, tissue factor, and thrombin 540


107 Novel oral anticoagulants 545


108 Aspirin for venous thromboembolism 552


109 Immediate therapeutic levels of heparin in relation to timing of recurrent events, 555


110 Intermittent pneumatic compression 558


111 Graduated compression stockings 561


112 Ankle exercise and venous blood velocity 565


113 Thrombolytic therapy for deep venous thrombosis 567


114 Mechanical and ultrasonic enhancement of catheter–directed thrombolytic therapy for deep venous thrombosis 572


115 Thrombolytic therapy for treatment of acute pulmonary embolism 574


116 Catheter–tip embolectomy in the management of acute massive pulmonary embolism 589


117 Vena cava filters 597


118 Withholding treatment of patients with acute pulmonary embolism who have a high risk of bleeding provided and negative serial noninvasive leg tests 615


119 Home treatment of deep venous thrombosis 617


120 Home treatment of acute pulmonary embolism 622


121 Pulmonary embolectomy 626


122 Chronic thromboembolic pulmonary hypertension and pulmonary thromboendarterectomy 634


123 Prevention and treatment of deep venous thrombosis and acute pulmonary embolism: American College of Chest Physicians Guidelines 639


Index 647


PRODUCT DETAILS

ISBN-13: 9781119039082
Publisher: John Wiley & Sons Ltd (Wiley–Blackwell)
Publication date: July, 2016
Pages: 704
Weight: 571g
Availability: Not yet published
Subcategories: Diseases and Disorders, Respiratory Medicine

MEET THE AUTHOR

Paul D. Stein MD,Professor of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA.


Dr. Stein′s major research in recent years has been in the field of venous thromboembolism. Dr. Stein initiated the PIOPED II and PIOPED III national collaborative studies and was national principal investigator and chairperson of the steering committees. He has written over 240 articles on venous thromboembolism from among over 560 peer reviewed articles. Dr Stein is a past president of the Laennec Society and of the American College of Chest Physicians. He is Fellow of the American College of Physicians and the American College of Cardiology and a Master Fellow of the American College of Chest Physicians. He is also a Fellow of the American Society of Mechanical Engineers. Fellowship is reserved for those who have made a significant contribution to the field of mechanical engineering. He received the Lifetime Achievement Award from the American Heart Association Midwest Affiliate, the Laureate Award of the American College of Physicians, Michigan Chapter, the Daniel Drake Award from the University of Cincinnati College of Medicine, and the Research Excellence Award from the Michigan State University College of Osteopathic Medicine.  Dr. Stein also wrote a book, A Physical and Physiological Basis for the Interpretation of Cardiac Auscultation:  Evaluations Based Primarily on Second Sound and Ejection Murmurs.

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