This book provides a thorough and comprehensive reference in the management of pruritus, designed to be a convenient resource for all physicians confronted with patients suffering from itch. The Editors have recruited a board of internationally renowned experts to provide an in-depth analysis of the causes and management of pruritus, including the current concepts in pathophysiology and novel therapeutics. Acute and chronic pruritus can represent significant management issues both as a common physiological sensation and as a manifestation of dermatologic and non-dermatologic diseases. All patients suffering from itch know that it is a very awkward sensation. Unfortunately, this often significant symptom is frequently considered less severe in comparison with pain. The consequences are that research on this field has been poorer than research on pain and that pruritus is therefore more difficult to treat. Pruritus, Second edition addresses the new concepts and discoveries that have modified our understanding of this condition. It explains the pathophysiology of itch, describes all causes, and provides guidelines for management and treatment.
1. Neural Processing of Itch.- 2.Pruriceptors.- 3. Central Representation of Itch.- 4.Interaction of Pruritus and Pain.- 5. Modulation of Pruritus: Peripheral and Central Sensitization.- 6.In vitro models of itch.- 7. Measurement of Sensory Function in Chronic Pruritus.- 8. Pruritus, Pain and Other Abnormal Skin Sensations.- 9. Epidemiology.- 10. Classification.- 11. Examination of Patients.- 12. Measurement of Itch: Patient-Reported Outcomes.- 13. Measurement of Itch: Actigraphy.- 14. Placebo and Nocebo Effects on Itch: Methodological and Clinical Implications.- 15. Patient Needs and Treatment Goals in Clinical Care of Chronic Pruritus.- 16. Sex- and Gender-Specific Differences in Chronic Pruritus.- 17. Clinical Presentation of Itch.- 18. Sensitive Skin.- 19. Atopic Dermatitis.- 20. Allergic and Irritant Contact Dermatitis.- 21. Urticaria.- 22.Mastocytosis.- 23. Cutaneous Drug Reactions and Drug-Induced Pruritus.- 24. Psoriasis.- 25. Autoimmune Diseases.- 26. Itch, Infections and Infestations.- 27. Cutaneous Lymphoma.- 28. Neuropathic Pruritus.- 29. Notalgia Paresthetica.- 30. Brachioradial Pruritus.- 31. Other Forms of Neuropathic Pruritus.- 32. Small-Fibre Neuropathies.- 33. Chronic Kidney Diseases.- 34.Hepatobiliary Diseases.- 35. Endocrine Diseases.- 36. Pruritus in Hematological Diseases (Including Aquagenic Pruritus).- 37. Cancers.- 38. The Burden Of Itch.- 39. Psychological Approach.- 40. Psychosomatic Aspects and Psychiatric Conditions.- 41. Psychogenic Pruritus..- 42. Pruritus in Children.- 43. Pruritus Vulvae.- 44.General Principles and Guidelines.- 45. Capsaicin.- 46. Topical Steroids and Immunomodulators.- 47. Menthol, Camphor and Other Topical Treatments.- 48. Antihistamines.- 49. Anticonvulsants.- 50. Opioid Receptor Antagonists or Agonists.- 51. Antidepressants.- 52. Immunosuppressants.- 53. NK-1 Antagonists.- 54. Psychological Intervention.- 55. Ultraviolet Phototherapy of Pruritus.- 56. Acupuncture.- 57.Future Perspectives: New and Modern Therapies.-