Main description:

The "Progress in Cell Cycle Research" series is dedicated to serve as a collection of reviews on various aspects of the cell division cycle, with special emphasis on less studied aspects. We hope this series will continue to be helpful to students, graduates and researchers interested in the cell cycle area and related fields. We hope that reading of these chapters will constitute a "point of entry" into specific aspects of this vast and fast moving field of research. As PCCR4 is being printed several other books on the cell cycle have appeared (ref. 1-3) which should complement our series. This fourth volume of PCCR starts with a review on RAS pathways and how they impinge on the cell cycle (chapter 1). In chapter 2, an overview is presented on the links between cell anchorage -cytoskeleton and cell cycle progression. A model of the Gl control in mammalian cells is provided in chapter 3. The role of histone acetylation and cell cycle contriol is described in chapter 4. Then follow a few reviews dedicated to specific cell cycle regulators: the 14-3-3 protein (chapter 5), the cdc7/Dbf4 protein kinase (chapter 6), the two products of the pI6/CDKN2A locus and their link with Rb and p53 (chapter 7), the Ph085 cyclin-dependent kinases in yeast (chapter 9), the cdc25 phophatase (chapter 10), RCCI and ran (chapter 13). The intriguing phosphorylation dependent prolyl-isomerization process and its function in cell cycle regulation are reviewed in chapter 8.

Contents:

Preface. Relationship between RAS pathways and cell cycle control; M.E. Ewen. Cell-Anchorage, cell cytoskeleton, and Rho-GTPase family in regulation of cell cycle progression; I. Tatsuno, et al. The Continuum model and G1-control of the mammalian cell cycle; S. Cooper. Histone acetylation and the control of the cell cycle; L. Magnaghi-Jaulin, et al. 14-3-3. proteins and growth control; V. Baldin. A Cdc7p-Dbf4 protein kinase activity is conserved from yeast to humans; L.H. Johnston, et al. Alternative product of the p16/CKDN2A locus connects the Rb and p53 tumor suppressors; M.C. James, G. Peters. Phosphorylation-dependent prolyl isomerization: a novel cell cycle regulatory mechanism; K.P. Lu. Functions of Pho85 cyclin-dependent kinases in budding yeast; J. Moffat, et al. Cell cycle regulation by the Cdc 25 phosphatase family; I. Nilsson, I. Hoffmann. Molecular mechanisms of the initiation of oocyte maturation: general and species-specific aspects; M. Yamashita, et al. The activation of MAP kinase and p34 cdc2/cyclin B during the meiotic maturation of Xenopus oocytes; A. Palmer, A.R. Nebreda. Premature chromatin condensation caused by loss of RCC1; H. Nishijima, et al. HTLV-I tax and cell cycle progression; C. Neuveut, K.-T. Jeang. The cell cycle in protozoan parasites; C. Doerig, et al. Circadian control of cell division in unicellular organisms; M. Tetsuya, C.H. Johnson. Circadian variation of cell proliferation and cell cycle protein expression in man: clinical implicatikons; G. Bjarnason, R. Jordan. Molecular switches that govern the balance between proliferation and apoptosis; B. Schutte, F.C.S. Ramaekers. Molecular events that regulate cell proliferation: an approach for the development of new anticancer drugs; E. Damiens. Abortive oncogeny and cell cycle-mediated events in Alzheimer disease; A.K. Raina, et al. Contributors. Index.