BOOKS BY CATEGORY
Your Account
Processing of VEGF-C and -D by the Proprotein Convertases
Importance in Angiogenesis, Lymphangiogenesis, and Tumorigenesis
Price
Quantity
€75.64
(To see other currencies, click on price)
Paperback / softback
Add to basket  

MORE ABOUT THIS BOOK

Main description:

The vascular endothelial growth factor (VEGF) family members that include VEGF-A, -B, -C, -D, and placental growth factor (PlGF), display distinct binding affinities for their receptors VEGFR-1, -2, and/or -3. In addition to their requirements in the initiation, development, and maintenance of blood and lymphatic vasculature, VEGFs and VEGFRs are upregulated during neoplasia and are involved in the remodeling of tumoral blood and lymphatic vasculature. By activating VEGFR-1 and VEGFR-2, both expressed on blood endothelial cells, VEGF-A promotes the formation of new tumoral blood vessels and thereby accelerates tumor growth. In contrast, upregulation of VEGF-C, a ligand for lymphatic endothelial VEGFR-3 as well as for VEGFR-2, induces the formation of tumor-associated lymphatic vessels and thus promotes the passive metastatic dissemination of tumor cells to regional lymph nodes. Of the VEGF family members, only VEGF-C and -D were found to be proteolytically processed by Furin-like enzymes. This processing controls the selective activation of VEGFR-2 and -3 signaling during tumor angiogenesis and lymphangiogenesis. Here, we provide an overview of angiogenesis processes and discuss the importance of VEGF-C and VEGF-D precursors processing by the proprotein convertases during the activation of VEGFR-2 and VEGFR-3 receptors and the mediation of their functions during angiogenesis, lymphangiogenesis, and tumorigenesis.


Contents:

Abbreviations
Acknowledgments
Angiogenesis: A Global Overview
VEGF Family Members, Their Receptors, and Signaling
Activation, Signaling, and Function of VEGFRs
The Role of VEGF Family Members in Tumor Angiogenesis and Lymphangiogenesis
Maturation of VEGF-C and VEGF-D by the Proprotein Convertases
References
Author Biographies


PRODUCT DETAILS

ISBN-13: 9781615046102
Publisher: Morgan & Claypool Publishers
Publication date: November, 2013
Pages: 66
Weight: 139g
Availability: Available
Subcategories: Biochemistry

CUSTOMER REVIEWS

Average Rating