Main description:

Dendrimers, which are hyperbranched synthetic macromolecules, have attracted researchers' increasing interest over the last three decades owing to their numerous properties, in particular, in the fields of biology and nanomedicine. This book is an up-to-date collection of the most recent achievements in the use of dendrimers in nanomedicine, exemplified by phosphorus-containing dendrimers. Starting with the synthesis and characterization of phosphorus dendrimers, the book discusses their use as biomaterials, carriers of biological entities, and anti-inflammatory drugs; in bioimaging; and against prion diseases, Alzheimer's, HIV, and cancer. It compares phosphorus dendrimers with other types of dendrimers. Supplemented with numerous references and abundant illustrations, the book opens new perspectives for the researchers working on dendrimers.

Contents:

Syntheses of Phosphorus Dendrimers. Methods for Characterizing (Phosphorus) Dendrimers. EPR Characterization of Phosphorous Dendrimers as Drugs for Cancer and Neurodegenerative Diseases. Fluorescent (Phosphorus) Dendrimers and Their Use for Biology. Biomaterials Made of Phosphorus Dendrimers: Towards Diagnosis Tools. PPH-Based Dendrimers as HIV Entry Inhibitors. Role of Dendrimers in the Development of New Dendritic Cells Immunotherapies against HIV-1 Infection. Phosphorus Dendrimers as Vectors for Gene Therapy in Cancer. First-in-Class Anticancer Nanoparticle Copper(II) Phosphorus Dendrimers as Proapoptotic Bax Activators. Rational Design of Mannodendrimers Targeting Human C-Type Lectin Receptors to Prevent Lung Inflammation. Phosphorus-Containing Dendrimers against Diseases of the Central Nervous System. The ABP Dendrimer Saga. Dendrimer Space Concept: A Futuristic Vision in Nanomedicine to Develop New Drugs. DNA-Based Multiplexing Technology for Rapid and Accurate Diagnosis of Pathogens: An Original Contribution of Phosphorus Dendrimers.