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Nucleic Acid Therapeutics in Cancer
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Main description:

A cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically.


Back cover:

The development of effectively targeted and efficiently delivered nucleic acids promises important advances in the diagnosis and treatment of human malignancies. In Nucleic Acid Therapeutics in Cancer, leading researchers, academic physicians, and clinicians clearly and succinctly review the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting methods and specific clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically.

Concise yet highly readable, Nucleic Acid Therapeutics in Cancer offers those who require a cutting-edge critical synthesis not only a state-of-the-art account of this promising field, but also an illuminating introduction to their emerging therapeutic uses.


Contents:

Part I. Introduction and Perspective

Antisense Methodology: An Assessment After 25 Years
Fritz Eckstein

Nucleic Acid Therapeutics: An Introduction
Alan M. Gewirtz

Part II. Basic Methodology

Targeted Genome Modification Via Triple Helix Formation
Faye A. Rogers and Peter M. Glazer

Therapeutic Applications of Ribozymes
John J. Rossi

Use of Catalytic DNA in Target Validation and Therapeutics
Lun-Quan Sun

Targeted Destruction of Small, Stable RNAs: Principles Applicable to Antisense Therapies
David A. Dunbar and Susan J. Baserga

Mechanism of Action of Antisense RNA in Eukaryotic Cells
Zuo Zhang and Gordon G. Carmichael

Part III. Delivery

The Transport of Oligonucleotides Into Cells
R. L. Juliano

Peptide-Mediated Delivery of Antisense Oligonucleotides and Related Material
Eric Vivès, Jean Philippe Richard, and Bernard Lebleu

Molecular Vectors for Gene Delivery to Cancer Cells
Guy Zuber, Jean-Serge Remy, Patrick Erbacher, Pascale Belguise, and Jean-Paul Behr

Part IV. Targeting

Considerations on the Design of Antisense Oligonucleotides
Rosel Kretschmer-Kazemi Far, Jens M. Warnecke, and Georg Sczakiel

Identification of Hybridization Accessible Sequence in Messenger RNA
Lida K. Gifford, Ponzy Lu, and Alan M. Gewirtz

Part V. Clinical Targets

Nucleic Acids As Gene Targeting Therapeutics
Joanna B. Opalinska and Susan E. Shetzline

LY900003 (Isis 3521) and G3139 (Genasense; Oblimersen): Phosphorothioate Antisense Oligonucleotides With Pleiotropic Mechanisms of Action
C. A. Stein, Nathalie Dias, Luba Benimetskaya, Jan S. Jepsen, Johnathan C. H. Lai, and Anthony J. Raffo

Antisense Protein Kinase A-RIa Restores Normal Signal Transduction Signatures to Inhibit Tumor Growth
Yoon S.Cho-Chung

Index


PRODUCT DETAILS

ISBN-13: 9781468498585
Publisher: Springer (Humana Press)
Publication date: July, 2012
Pages: 221
Weight: 345g
Availability: POD
Subcategories: Oncology
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