Main description:

First published in 1991: This book assimilates and evaluates the rapidly accumulating information regarding neuropeptides in the gut, their chemistry; genetic control; processing in enteric nerves; the projections of their nerves; their actions at the tissue, cell, and molecular levels; and their roles in controlling gut motility in health and disease. Neuropeptide Function in the Gastrointestinal Tract is directed to scientists in all disciplines who work with neuropeptides, as well as physiologists interested in the neural and smooth muscle actions of neuropeptides.

Contents:

1. A Historical Overview of the Gastroenteropancreatic Regulatory Peptides

T.J. McDonald

2. Gastroenteropancreatic Regulatory Peptides Structures: An Overview

T.J. McDonald

3. Regulation of Gastrointestinal Neuropeptide Gene Expression and Processing

Ake Rokaeus

4. Microanatomy and Chemical Coding of Peptide-Containing Neurons in the Digestive Tract

E. Ekblad, R Hakanson, and F. Sundler

5. Neuropeptide Motor Actions Vary between In Vivo and In Vitro Experimental Conditions

Jo-Ann E.t. Fox-Thelkeld

6. Receptors for Neuropeptides (Neurokinins) : Functional Studies

D. Regoli, S. Dion, and G. Drapeau

7. Receptors for Neuropeptides: Ligand Binding Studies

Sultan Ahmad, H.D. Allescher, and C.Y. Kwan

8. Receptors for Neuropeptides: Receptors Isolation Studies and Molecular Biology

Jean-Pierre Vincent and Patrick Kitabgi

9. Gastrointestinal Neuropeptides and Second Messenger Systems

Peter Kostka

10. Gastrointestinal Neuropeptide-Inactivating Mechanisms in the Circulation and in the Gastrointestinal Tract

Frederic Checler

11. Postulated Physiological and Pathophysiological Roles on Motility

Hans-Dieter Allescher and Sultan Ahmad

12. Physiological and Pathophysiological Roles of VIP, Somatostatin, Opioids, Galanin, GRP, and Secretin

Jan D. Huizinga and Julio Pintin-Quezada

13. Effects of Neuropeptides on Intestinal Ion Transport

P.K. Rangachari

14. The Role of Neuropeptides in the Normal and Pathophysiological Control of Blood Flow

John S. Smeda

15. Neuropeptides and Cell Proliferation

David J. Hill

16. Perspectives for the Study of Gut Neuropeptides

E.E. Daniel