Main description:

Aimed at "drug discoverers" - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.

Contents:

1. Protein misfolding, neurodegeneration and Tau: The main players, or the usual suspects? 2. Targeting the protein quality control (PQC) machinery: The neuronal Salvation Army 3. Proteasomal degradation of soluble, misfolded proteins: Throwing out the bath water, but where's the baby? 4. Unselective disposal of cellular aggregates: Engulf, devour and digest to recycle 5. Selective disposal of insoluble protein aggregates: Pick, transport and remove to cure 6. Assembly and disassembly of protein aggregates: Unraveling the maze