Main description:

Modern mechanobiology converges both engineering and medicine to address personalized medicine. This book is built on the previously well-received edition, Hemodynamics and Mechanobiology of Endothelium. The central theme is "omic" approaches to mechanosignal transduction underlying tissue development, injury, and repair. A cadre of investigators has contributed to the chapters, enriching the interface between mechanobiology and precision medicine for personalized diagnosis and intervention. The book begins with the fundamental basis of vascular disease in response to hemodynamic shear stress and then details cardiovascular development and regeneration, valvular and cardiac morphogenesis, mechanosensitive microRNA and histone unfolding, computational fluid dynamics, and light-sheet imaging. This edition represents a paradigm shift from traditional biomechanics and signal transduction to transgenic models, including novel zebrafish and chick embryos, and targets a wider readership from academia to industry and government agencies in the field of mechanobiology.

Contents:

1. Shear Stress, Mechanosensors, and Atherosclerosis 2. Role of Kruppel-Like Factors in Endothelial Cell Function and Shear Stress-Mediated Vasoprotection 3. Aortic Valve Endothelium Mechanobiology 4. Mechanotransduction of Cardiovascular Development and Regeneration 5. Mechanotransduction in Heart Formation: An Avian Model for Regulating Hemodynamics 6. Mechanotransduction in Cardiovascular Development and Regeneration: A Zebrafish Model for Genetic Manipulation 7. Mechanosensitive microRNAs in Health and Disease 8. Mechanotransduction to the Cell Nucleus 9. Computation of Congenital Heart Disease: A Sheep Model 10. Integrating Light-Sheet Imaging and Shear Stress-Mediated Notch Signaling to Elucidate Cardiac Trabeculation for Contractile Function