Main description:

This practical book is part of the new "Artech House Methods in Bioengineering" series - volumes designed to offer detailed guidance on authoritative methods for addressing specific bioengineering challenges. Written and edited by recognized experts in the field, each book provides research engineers, scientists, and students with step-by-step procedures, clear examples, and effective ways to overcome problems that may be encountered. This volume focuses on the design of state-of-the art methods for investigating complex biological systems and the development of complex models to analyze the data. Professionals find how-to guidance on experimental approaches for investigating cellular behavior in health and disease.

Contents:

Development of Green Fluorescent Protein-Based Reporter Cell Lines for Dynamic Profiling of Transcription Factor and Kinase Activation. Data-driven, Mechanistic Modeling of Biochemical Reaction Networks. Construction of Phenotype-Specific Gene Network by Synergy Analysis. Genome Scale Analysis of Metabolic Networks. Modeling the Dynamics of Cellular Networks. Determining Metabolite Production Capabilities of Engineered Saccharomyces cerevisiae using Dynamic Flux Balance Analysis. Parameter Identification with Adaptive Sparse Grid-based Optimization for Models of Cellular Processes. Reverse Engineering of Biological Networks. Transcriptome Analysis of Regulatory Networks.