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Lung Stem Cells in Development, Health and Disease
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Main description:

Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science.


Contents:

Lung development; Alveolar stem cells in lung development and regrowth; Lung blood and lymphatic vascular development; Neuroendocrine cells in lung development and disease; Adult mouse and human airway epithelial basal stem cells; Stem cells of submucosal glands: their function as tissue stem cells and a reserve population for airway repair; Adult mouse intralobar airway stem cells; Evidence for the involvement of lipofibroblasts, airway smooth muscle cells and FGF10 signalling in lung repair; Respiratory bronchioles: a unique structure in the human lung; Alveolar epithelial stem cells in homeostasis and repair; Mesenchymal cells, immune cells and the lung stem cell niche; Endothelial cells in the lung; The Human Lung Cell Atlas: a transformational resource for cells of the respiratory system; Lung organoids: powerful tools for studying lung stem cells and diseases; Induced pluripotent stem cells for generating lung airway stem cells and modelling respiratory disease; Induced pluripotent stem cells for generating lung alveolar epithelial cells and modelling respiratory disease; Three-dimensional tissue-based models for translational lung stem cell research: precision-cut lung slices; The use of pre-conditioning and novel assays in the development of protocols for transplantation of lung progenitors; Lung tissue bioengineering for transplantation and modelling of development, disease and regeneration; Ferret respiratory disease models for the study of lung stem cells; Epithelial stem cells at the intersection of tissue regeneration and pulmonary fibrosis; Lung stem cells and therapy for cystic fibrosis; The role of altered stem cell function in airway and alveolar repair and remodelling in COPD; Stem cells and lung cancer; Progress and potential of mesenchymal stromal cell therapy in acute respiratory distress syndrome; The next 10 years in lung stem cell research


PRODUCT DETAILS

ISBN-13: 9781849841337
Publisher: European Respiratory Society
Publication date: April, 2021
Pages: None
Weight: 652g
Availability: Contact supplier
Subcategories: Respiratory Medicine

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