Main description:

James J. Goedert and a team of leading experimental and clinical researchers provide critical, integrating surveys of those viruses, bacteria, and parasites that are now known to play a major role in cancer-work that opens the way toward novel therapeutic targets. The contributors focus on five types of human carcinogenic infection-herpesviruses, retroviruses, papillomaviruses, hepatitis viruses, and H. pylori-and review in depth the associated malignancies, as well as how these new diagnostic and therapeutic technologies may be implemented. Cutting-edge and cross-disciplinary, Infectious Causes of Cancer: Targets for Intervention provides clinical oncologists and infectious disease specialists, as well as clinical researchers, with insightful reviews of cancer induction by infectious diseases and the high promise of closely targeted new therapeutics and vaccines.

Contents:

Part I. Background. History of Infectious Disease Oncology, from Galen to Rous, John Graner. Part II. Herpesviruses. Overview of Herpesviruses, Frank J. Jenkins and Linda J. Hoffman. X-Linked Lymphoproliferative Disease, Thomas A. Seemayer, Timothy G. Greiner, Thomas G. Gross, Jack R. Davis, Arpad Lanyi, and Janos Sumegi. Posttransplant Lymphoproliferative Disorder, Lode J. Swinnen. Epstein-Barr Virus and Burkitt's Lymphoma, Guy de The. Epstein-Barr Virus and Nasopharyngeal Carcinoma, Nancy Raab-Traub. Hodgkin's Disease, Paula G. O'Connor and David T. Scadden. AIDS-Related Lymphoma, Alexandra M. Levine. Leiomyoma and Leiomyosarcoma, Hal B. Jenson. Kaposi's Sarcoma and Other HHV-8-Associated Tumors, Chris Boshoff. Part III. Retroviruses. Retroviruses and Cancer, Robin A. Weiss. Adult T-Cell Leukemia/Lymphoma, Masao Matsuoka. Clonal HIV in the Pathogenesis of AIDS-Related Lymphoma: Sequential Pathogenesis, Michael S. McGrath, Bruce Shiramizu, and Brian G. Herndier. Part IV. Papillomaviruses. Papillomaviruses in Human Cancers, Harald zur Hausen. Anogenital Squamous Cell Cancer and Its Precursors: Natural History, Diagnosis, and Treatment, Joel M. Palefsky. Human Papillomaviruses and Cancers of the Skin and Oral Mucosa, Irene M. Leigh, Judy A. Breuer, John A. G. Buchanan, Catherine A. Harwood, Sarah Jackson, Jane M. McGregor, Charlotte M. Proby, and Alan Storey. Part V. Hepatitis Viruses. Overview of Hepatitis B and C Viruses, Jia-Horng Kao and Ding-Shinn Chen. Hepatocellular Carcinoma, Michael C. Kew. Hepatitis C Virus, B-Cell Disorders, and Non-Hodgkin's Lymphoma, Clodoveo Ferri, Stefano Pileri, and Anna Linda Zignego. Part VI. Bacterial and Helminthic Oncology. Overview of Helicobacter pylori, James G. Fox and Timothy C. Wang. Gastric Adenocarcinoma, Catherine Ley and Julie Parsonnet. Gastric Mucosa-Associated Lymphoid Tissue Lymphoma, Andrew C. Wotherspoon. Salmonella typhi/paratyphi and Gallbladder Cancer, Christine P. J. Caygill and Michael J. Hill. Schistosomahematobium and Bladder Cancer, Monalisa Sur and Kum Cooper. Part VII. Other Infections and Human Neoplasms. Does Childhood Acute Lymphoblastic Leukemia Have an Infectious Etiology?, Mel F. Greaves. Polyoma Viruses (JC Virus, BK Virus, and Simian Virus 40) and Human Cancer, Keerti V. Shah. In Pursuit of a Human Breast Cancer Virus, from Mouse to Human, Marjorie Robert-Guroff and Gertrude Case Buehring. Index.